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    Intrinsically connected: therapeutically targeting the cathepsin proteases and the Bcl-2 family of protein substrates as co-regulators of apoptosis

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    Authors
    Soond, S. M.
    Kozhevnikova, M. V.
    Savvateeva, L. V.
    Townsend, Paul A
    Zamyatnin, A. A., Jr.
    Affiliation
    Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, 119991 Moscow, Russi
    Issue Date
    2021
    
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    Abstract
    Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic design and development is coming into fruition. Underpinning this approach is the invariable progression from the direction of fully characterizing cathepsin protease members and their substrate targets, towards targeting such an interaction with tangible therapeutics. The two groups of such substrates that have gained much attention over the years are the pro- and anti- apoptotic protein intermediates from the extrinsic and intrinsic signaling arms of the apoptosis pathway. As proteins that are central to determining cellular fate, some of them present themselves as very favorable candidates for therapeutic targeting. However, considering that both anti- and pro- apoptotic signaling intermediates have been reported to be downstream substrates for certain activated cathepsin proteases, therapeutic targeting approaches based on greater selectivity do need to be given greater consideration. Herein, we review the relationships shared by the cathepsin proteases and the Bcl-2 homology domain proteins, in the context of how the topical approach of adopting 'BH3-mimetics' can be explored further in modulating the relationship between the anti- and pro- apoptotic signaling intermediates from the intrinsic apoptosis pathway and their upstream cathepsin protease regulators. Based on this, we highlight important future considerations for improved therapeutic design.
    Citation
    Soond SM, Kozhevnikova MV, Savvateeva LV, Townsend PA, Zamyatnin AA Jr. Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis. IJMS. 2021 Apr 28;22(9):4669.
    Journal
    International Journal of Molecular Sciences
    URI
    http://hdl.handle.net/10541/624057
    DOI
    10.3390/ijms22094669
    PubMed ID
    33925117
    Additional Links
    https://dx.doi.org/10.3390/ijms22094669
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms22094669
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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