Show simple item record

dc.contributor.authorErickson, A.
dc.contributor.authorHayes, A.
dc.contributor.authorRajakumar, T.
dc.contributor.authorVerill, C.
dc.contributor.authorBryant, R. J.
dc.contributor.authorHamdy, F. C.
dc.contributor.authorWedge, David C
dc.contributor.authorWoodcock, D. J.
dc.contributor.authorMills, I. G.
dc.contributor.authorLamb, A. D.
dc.date.accessioned2021-05-18T08:48:18Z
dc.date.available2021-05-18T08:48:18Z
dc.date.issued2021en
dc.identifier.citationErickson A, Hayes A, Rajakumar T, Verrill C, Bryant RJ, Hamdy FC, et al. A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease. European Urology Oncology. 2021 Apren
dc.identifier.pmid33888445en
dc.identifier.doi10.1016/j.euo.2021.02.008en
dc.identifier.urihttp://hdl.handle.net/10541/624056
dc.description.abstractContext: Studies characterising genomic changes in prostate cancer (PCa) during natural progression have greatly increased our understanding of the disease. A better understanding of the evolutionary history of PCa would allow advances in diagnostics, prognostication, and novel therapies that together will improve patient outcomes. Objective: To review the molecular heterogeneity of PCa and assess recent efforts to profile intratumoural heterogeneity and clonal evolution. Evidence acquisition: We screened a total of 1313 abstracts from PubMed published between 2009 and 2020, of which we reviewed 84 full-text articles. We excluded 49, resulting in 35 studies for qualitative analysis. Evidence synthesis: In studies of primary disease (16 studies, 4793 specimens), there is a lack of consensus regarding the monoclonal or polyclonal origin of primary PCa. There is no consistent mutation giving rise to primary PCa. Detailed clonal analysis of primary PCa has been limited by current techniques. By contrast, clonal relationships between PCa metastases and a potentiating clone have been consistently identified (19 studies, 732 specimens). Metastatic specimens demonstrate consistent truncal genomic aberrations that suggest monoclonal metastatic progenitors. Conclusions: The relationship between the clonal dynamics of PCa and clinical outcomes needs further investigation. It is likely that this will provide a biological rationale for whether radical treatment of the primary tumour benefits patients with oligometastatic PCa. Future studies on the mutational burden in primary disease at single-cell resolution should permit the identification of clonal patterns underpinning the origin of lethal PCa. Patient summary: Prostate cancers arise in different parts of the prostate because of DNA mutations that occur by chance at different times. These cancer cells and their origin can be tracked by DNA mapping. In this review we summarise the state of the art and outline what further science is needed to provide the missing answers.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.euo.2021.02.008en
dc.titleA systematic review of prostate cancer heterogeneity: understanding the clonal ancestry of multifocal diseaseen
dc.typeArticleen
dc.contributor.departmentNuffield Department of Surgical Sciences, University of Oxford, Oxforden
dc.identifier.journalEuropean Urology Oncologyen
dc.description.noteen
refterms.dateFOA2021-05-19T08:49:36Z


Files in this item

Thumbnail
Name:
33888445.pdf
Size:
1.082Mb
Format:
PDF
Description:
From UNPAYWALL

This item appears in the following Collection(s)

Show simple item record