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A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans

dc.contributor.authorHalova, Lenka
dc.contributor.authorCobley, D.
dc.contributor.authorFranz-Wachtel, M.
dc.contributor.authorWang, T.
dc.contributor.authorMorrison, K. R.
dc.contributor.authorKrug, K.
dc.contributor.authorNalpas, N.
dc.contributor.authorMaček, B.
dc.contributor.authorHagan, Iain M
dc.contributor.authorHumphrey, S. J.
dc.contributor.authorPetersen, J.
dc.date.accessioned2021-05-18T08:48:15Z
dc.date.available2021-05-18T08:48:15Z
dc.date.issued2021en
dc.identifier.citationHalova L, Cobley D, Franz-Wachtel M, Wang T, Morrison KR, Krug K, et al. A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans. Open Biol. 2021 Apr;11(4).en
dc.identifier.pmid33823663en
dc.identifier.doi10.1098/rsob.200405en
dc.identifier.urihttp://hdl.handle.net/10541/624041
dc.description.abstractFluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in the fission yeast Schizosaccharomyces pombe. Phosphorylation levels at more than 1000 sites were altered following nitrogen stress or Torin1 inhibition of the TORC1 and TORC2 networks that comprise TOR signalling. One hundred and thirty of these sites were regulated by both perturbations, and the majority of these (119) new targets have not previously been linked to either nutritional or TOR control in either yeasts or humans. Elimination of AMPK inhibition of TORC1, by removal of AMPKα (ssp2en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1098/rsob.200405en
dc.titleA TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humansen
dc.typeArticleen
dc.contributor.departmentFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT UKen
dc.identifier.journalOpen Biologyen
dc.description.noteen
refterms.dateFOA2021-05-18T13:15:35Z


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