Show simple item record

dc.contributor.authorSutton, Paul A
dc.contributor.authorO'Dwyer, Sarah T
dc.contributor.authorBarriuso, Jorge
dc.contributor.authorAziz, Omer
dc.contributor.authorSelvasekar, Chelliah
dc.contributor.authorRenehan, Andrew G
dc.contributor.authorWilson, Malcolm S
dc.date.accessioned2021-05-18T08:48:10Z
dc.date.available2021-05-18T08:48:10Z
dc.date.issued2021en
dc.identifier.citationSutton PA, O’Dwyer ST, Barriuso J, Aziz O, Selvasekar CR, Renehan AG, et al. Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy. Surgical Oncology. 2021 Sep;38:101572.en
dc.identifier.pmid33915487en
dc.identifier.doi10.1016/j.suronc.2021.101572en
dc.identifier.urihttp://hdl.handle.net/10541/624024
dc.description.abstractIntroduction: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is offered in specialist centres as a treatment for peritoneal surface tumours. Despite its demonstrated efficacy, intra-abdominal recurrence occurs in 31-57% of patients. The aim of this study is to review the early and long-term outcomes in patients who undergo repeat CRS/HIPEC. Materials and methods: A retrospective review of a prospectively maintained database of patients who had undergone repeat CRS/HIPEC for appendiceal neoplasms and colorectal peritoneal metastases (CRPM) from 2003 to 2019 was performed at a single specialist centre. Data pertaining to both short term outcomes and survival were evaluated. Results: Of 1259 patients who had undergone CRS/HIPEC, 84(6.7%) underwent repeat surgery: 45(53.6%) had pseudomyxoma peritonei (PMP) secondary to low grade appendiceal mucinous neoplasms (LAMN), 21(25.0%) had appendix carcinoma and 18(21.4%) had CRPM. Demographics, intra-operative findings and short-term outcomes were comparable across tumour types and between procedures. Median (95% CI) interval between procedures was 22.7(18.9-26.6) months and was comparable between tumour types. Median (95%CI) overall survival was not reached for the cohort overall or for those with PMP, but was 61.0(32.6-89.4) months for those with appendix cancer and 76.9(47.4-106.4) months for CRPM (p=<0.001). Survival was favourable in the PMP group (HR [95%CI] 0.044 [0.008-0.262]; p = 0.000) and unfavourable in the CC2-3 at index CRS procedure group (HR [95%CI] 25.612 [2.703-242.703]; p = 0.005). Conclusion: Our findings demonstrate that repeat cytoredutive surgery with HIPEC can result in favourable survival, especially for patients with PMP when complete cytoreduction is achieved at index operation. We recommend that detailed patient assessment is performed through an expert multidisciplinary team meeting (MDT).en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.suronc.2021.101572en
dc.titleIndications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancyen
dc.typeArticleen
dc.contributor.departmentColorectal and Peritoneal Oncology Centre, The Christie Hospital, UKen
dc.identifier.journalSurgical Oncologyen
dc.description.noteen


Files in this item

This item appears in the following Collection(s)

Show simple item record