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dc.contributor.authorSilkenstedt, E.
dc.contributor.authorLinton, Kim M
dc.contributor.authorDreyling, M.
dc.date.accessioned2021-04-20T08:08:24Z
dc.date.available2021-04-20T08:08:24Z
dc.date.issued2021en
dc.identifier.citationSilkenstedt E, Linton K, Dreyling M. Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches. Br J Haematol. 2021.en
dc.identifier.pmid33783838en
dc.identifier.doi10.1111/bjh.17419en
dc.identifier.urihttp://hdl.handle.net/10541/623958
dc.description.abstractMantle cell lymphoma (MCL) is clinically characterised by its heterogenous behaviour with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with a very limited prognosis. A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory/relapsed (R/R) disease. Nevertheless, to further optimise MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated into clinical patient management. The present review highlights recent advances in deciphering the molecular background of MCL, the definition of prognostically relevant factors and the identification of potential druggable targets and summarises current treatment recommendations for primary and R/R MCL including novel targeted therapies.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1111/bjh.17419en
dc.titleMantle cell lymphoma - advances in molecular biology, prognostication and treatment approachesen
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine III, LMU Hospital, Munich, Germanyen
dc.identifier.journalBritish Journal of Haematologyen
dc.description.noteen]
refterms.dateFOA2021-04-26T10:28:17Z


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