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    Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches

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    Authors
    Silkenstedt, E.
    Linton, Kim M
    Dreyling, M.
    Affiliation
    Department of Medicine III, LMU Hospital, Munich, Germany
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Mantle cell lymphoma (MCL) is clinically characterised by its heterogenous behaviour with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with a very limited prognosis. A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory/relapsed (R/R) disease. Nevertheless, to further optimise MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated into clinical patient management. The present review highlights recent advances in deciphering the molecular background of MCL, the definition of prognostically relevant factors and the identification of potential druggable targets and summarises current treatment recommendations for primary and R/R MCL including novel targeted therapies.
    Citation
    Silkenstedt E, Linton K, Dreyling M. Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches. Br J Haematol. 2021.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/623958
    DOI
    10.1111/bjh.17419
    PubMed ID
    33783838
    Additional Links
    https://dx.doi.org/10.1111/bjh.17419
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/bjh.17419
    Scopus Count
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