Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches
Affiliation
Department of Medicine III, LMU Hospital, Munich, GermanyIssue Date
2021
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Mantle cell lymphoma (MCL) is clinically characterised by its heterogenous behaviour with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with a very limited prognosis. A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory/relapsed (R/R) disease. Nevertheless, to further optimise MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated into clinical patient management. The present review highlights recent advances in deciphering the molecular background of MCL, the definition of prognostically relevant factors and the identification of potential druggable targets and summarises current treatment recommendations for primary and R/R MCL including novel targeted therapies.Citation
Silkenstedt E, Linton K, Dreyling M. Mantle cell lymphoma - advances in molecular biology, prognostication and treatment approaches. Br J Haematol. 2021.Journal
British Journal of HaematologyDOI
10.1111/bjh.17419PubMed ID
33783838Additional Links
https://dx.doi.org/10.1111/bjh.17419Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1111/bjh.17419
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