• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Genetic and non-genetic mechanisms underlying cancer evolution

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    33803675.pdf
    Size:
    5.863Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Shlyakhtina, Yelyzaveta
    Moran, Katherine L
    Portal, Maximiliano M
    Affiliation
    Cell Plasticity and Epigenetics Lab. Cancer Research UK-Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UK
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Cancer development can be defined as a process of cellular and tissular microevolution ultimately leading to malignancy. Strikingly, though this concept has prevailed in the field for more than a century, the precise mechanisms underlying evolutionary processes occurring within tumours remain largely uncharacterized and rather cryptic. Nevertheless, although our current knowledge is fragmentary, data collected to date suggest that most tumours display features compatible with a diverse array of evolutionary paths, suggesting that most of the existing macro-evolutionary models find their avatar in cancer biology. Herein, we discuss an up-to-date view of the fundamental genetic and non-genetic mechanisms underlying tumour evolution with the aim of concurring into an integrated view of the evolutionary forces at play throughout the emergence and progression of the disease and into the acquisition of resistance to diverse therapeutic paradigms. Our ultimate goal is to delve into the intricacies of genetic and non-genetic networks underlying tumour evolution to build a framework where both core concepts are considered non-negligible and equally fundamental.
    Citation
    Shlyakhtina Y, Moran KL, Portal MM. Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution. Cancers (Basel). 2021;13(6).
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/623957
    DOI
    10.3390/cancers13061380
    PubMed ID
    33803675
    Additional Links
    https://dx.doi.org/10.3390/cancers13061380
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13061380
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • The role of non-genetic information in evolutionary frameworks.
    • Authors: Moran KL, Shlyakhtina Y, Portal MM
    • Issue date: 2021 Jun
    • Intra-tumour heterogeneity - going beyond genetics.
    • Authors: Caiado F, Silva-Santos B, Norell H
    • Issue date: 2016 Jun
    • [Foundations of the new phylogenetics].
    • Authors: Pavlinov IIa
    • Issue date: 2004 Jul-Aug
    • Genetic and epigenetic determinants of B-cell lymphoma evolution.
    • Authors: Izzo F, Landau DA
    • Issue date: 2016 Jul
    • Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases.
    • Authors: Taujale R, Venkat A, Huang LC, Zhou Z, Yeung W, Rasheed KM, Li S, Edison AS, Moremen KW, Kannan N
    • Issue date: 2020 Apr 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.