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    Biological factors of the tumour response to electrochemotherapy: Review of the evidence and a research roadmap

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    Authors
    Sersa, G.
    Ursic, K.
    Cemazar, M.
    Heller, R.
    Bosnjak, M.
    Campana, Luca G
    Affiliation
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, SI-1000, Ljubljana, Slovenia
    Issue Date
    2021
    
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    Abstract
    The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deep-seated malignancies in terms of local control and quality of life are widely accepted. However, the variability in responses across histotypes needs to be explored. Currently, patient selection for ECT is based on clinical factors (tumour size, histotype, and exposure to previous oncological treatments), whereas there are no biomarkers to predict the response to treatment. In this field, two major areas of investigation can be identified, i.e., tumour cell characteristics and the tumour microenvironment (vasculature, extracellular matrix, and immune infiltrate). For each of these areas, we describe the current knowledge and discuss how to foster further investigation. This review aims to provide a summary of the currently used guiding clinical factors and delineates a research roadmap for future studies to identify putative biomarkers of response to ECT. These biomarkers may allow researchers to improve ECT practice by customising treatment parameters, manipulating the tumour and its microenvironment, and exploring novel therapeutic combinations.
    Citation
    Sersa G, Ursic K, Cemazar M, Heller R, Bosnjak M, Campana LG. Biological factors of the tumour response to electrochemotherapy: Review of the evidence and a research roadmap. Eur J Surg Oncol. 2021.
    Journal
    European Journal of Surgical Oncology
    URI
    http://hdl.handle.net/10541/623955
    DOI
    10.1016/j.ejso.2021.03.229
    PubMed ID
    33726951
    Additional Links
    https://dx.doi.org/10.1016/j.ejso.2021.03.229
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejso.2021.03.229
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