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    Supportive care for new cancer therapies

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    Authors
    Rapoport, B. L.
    Cooksley, Timothy J
    Johnson, D. B.
    Anderson, R.
    Affiliation
    Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria The Medical Oncology Centre of Rosebank, Johannesburg, South Africa
    Issue Date
    2021
    
    Metadata
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    Abstract
    Purpose of review: The past decade has witnessed unprecedented delivery to the clinical arena of a range of novel, innovative, and effective targeted anticancer therapies. These include immunotherapies, most prominently immune checkpoint inhibitors, as well as agents that target growth factors and cancer-related mutations. Many of these new cancer therapies are, however, associated with an array of toxicities, necessitating insight and vigilance on the part of attending physicians to achieve high-quality supportive care alongside toxicity management. In this review, we consider some of the key supportive care issues in toxicity management. Recent findings: Although both supportive care and targeted therapies have brought significant benefits to cancer care, the management of novel cancer therapy toxicities is nevertheless often complex. This is due in large part to the fact that target organs differ widely, particularly in the case of checkpoint inhibitors, with minor dermatological disorders being most common, while others, such as pneumonitis, are more severe and potentially life threatening. Accordingly, efficient management of these immune-related adverse events requires collaboration between multiple medical specialists. Summary: Supportive care is a key component in the management of new cancer therapy toxicities and needs to be incorporated into treatment pathways.
    Citation
    Rapoport BL, Cooksley T, Johnson DB, Anderson R. Supportive care for new cancer therapies. Curr Opin Oncol. 2021.
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/623954
    DOI
    10.1097/cco.0000000000000736
    PubMed ID
    33756517
    Additional Links
    https://dx.doi.org/10.1097/cco.0000000000000736
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1097/cco.0000000000000736
    Scopus Count
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