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    The role of 18F-Fluorodeoxyglucose PET/CT in restaging patients with small cell lung cancer: a systematic review

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    Authors
    Quartuccio, N.
    Salem, Ahmed
    Laudicella, R.
    Spataro, A.
    Chiaravalloti, A.
    Caobelli, F.
    Cistaro, A.
    Alongi, P.
    Evangelista, L.
    Affiliation
    Nuclear Medicine Unit, ARNAS Ospedali Civico, Di Cristina e Benfratelli, Palermo, Italy
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Aim: 18F-Fluorodeoxyglucose (FDG) PET imaging may play an important role in the restaging of patients with small-cell lung cancer (SCLC),, nevertheless, a systematic review of literature was still missing in this setting. The aim of this review was to summarize the evidence on literature regarding the utility of 18F-FDG PET imaging in restaging patients with SCLC. Methods: A literature search was performed to retrieve original studies using 18F-FDG PET or 18F-FDG PET/computed tomography (CT) in a minimum of 10 patients with SCLC at restaging. Results: The selected literature (17 studies) was discussed in four sections: detection rate, impact on management, prediction of prognosis and evaluation of the response to therapy. According to the literature, PET imaging may result in discordance with conventional imaging, mainly contrast-enhanced CT (ceCT), and detect additional lesions in a certain proportion of cases, leading to upstaging or downstaging. A variable level of disagreement between PET and conventional imaging has been reported also in the evaluation of response to therapy. A positive PET study is associated with shorter survival, especially in the presence of distant metastases. According to some studies, semiquantitative parameters are also inversely associated with overall survival and progression-free survival. Although the retrieved articles proved the utility of 18F-FDG PET imaging in each clinical setting, literature is still limited. Conclusions: This review encourages the use of 18F-FDG PET imaging, especially in conjunction with ceCT in recurrent SCLC patients. Further level I evidence is needed to further assess the diagnostic and prognostic capability of 18F-FDG PET/ceCT findings in SCLC.
    Citation
    Quartuccio N, Salem A, Laudicella R, Spataro A, Chiaravalloti A, Caobelli F, et al. The role of 18F-Fluorodeoxyglucose PET/CT in restaging patients with small cell lung cancer: a systematic review. Nucl Med Commun. 2021.
    Journal
    Nuclear Medicine Communications
    URI
    http://hdl.handle.net/10541/623953
    DOI
    10.1097/mnm.0000000000001407
    PubMed ID
    33741854
    Additional Links
    https://dx.doi.org/10.1097/mnm.0000000000001407
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1097/mnm.0000000000001407
    Scopus Count
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