• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Inter-clinician delineation ...
    Size:
    1.788Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Mul, J.
    Melchior, P.
    Seravalli, E.
    Saunders, Daniel
    Bolle, S.
    Cameron, A. L.
    Gurtner, K.
    Harrabi, S.
    Lassen-Ramshad, Y.
    Lavan, N.
    Magelssen, H.
    Mandeville, H.
    Boterberg, T.
    Kroon, P. S.
    Kotte, A.
    Hoeben, B. A. W.
    van Rossum, P. S. N.
    van Grotel, M.
    Graf, N.
    van den Heuvel-Eibrink, M. M.
    Rübe, C.
    Janssens, G. O.
    Show allShow less
    Affiliation
    Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Background and purpose: Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance. Materials and methods: Six pediatric renal cancer cases were transferred to ten radiation oncologists from seven European countries ('participants'). These participants delineated the pre- and postoperative Gross Tumor Volume (GTVpre/post), and Clinical Target Volume (CTV) during two test phases (case 1-2 and 3-4), followed by guideline refinement and a quality assurance phase (case 5-6). Reference target volumes (TVref) were established by three experienced radiation oncologists. The Dice Similarity Coefficient between the reference and participants (DSCref/part) was calculated per case. Delineations of case 5-6 were graded by four independent reviewers as 'per protocol' (0-4 mm), 'minor deviation' (5-9 mm) or 'major deviation' (≥10 mm) from the delineation guideline using 18 standardized criteria. Also, a major deviation resulting in underestimation of the CTVref was regarded as an unacceptable variation. Results: A total of 57/60 delineation sets were completed. The median DSCref/part for the CTV was 0.55 without improvement after sequential cases (case 3-4 vs. case 5-6: p = 0.15). For case 5-6, a major deviation was found for 5/18, 12/17, 18/18 and 4/9 collected delineations of the GTVpre, GTVpost, CTV-T and CTV-N, respectively. An unacceptable variation from the CTVref was found for 7/9 participants for case 5 and 6/9 participants for case 6. Conclusion: This international multicenter delineation exercise demonstrates that the new consensus for highly-conformal postoperative flank target volume delineation leads to geometrical variation among participants. Moreover, standardized review showed an unacceptable delineation variation in the majority of the participants. These findings strongly suggest the need for additional training and centralized pre-treatment review when this target volume delineation approach is implemented on a larger scale.
    Citation
    Mul J, Melchior P, Seravalli E, Saunders D, Bolle S, Cameron AL, et al. Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise. Clin Transl Radiat Oncol. 2021;28:39-47.
    Journal
    Clinical and Translational Radiation Oncology
    URI
    http://hdl.handle.net/10541/623945
    DOI
    10.1016/j.ctro.2021.03.001
    PubMed ID
    33796796
    Additional Links
    https://dx.doi.org/10.1016/j.ctro.2021.03.001
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctro.2021.03.001
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Estimated clinical benefit of combining highly conformal target volumes with Volumetric-Modulated Arc Therapy (VMAT) versus conventional flank irradiation in pediatric renal tumors.
    • Authors: Mul J, Seravalli E, Bosman ME, van de Ven CP, Littooij AS, van Grotel M, van den Heuvel-Eibrink MM, Janssens GO
    • Issue date: 2021 Jul
    • The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.
    • Authors: Janssens GO, Melchior P, Mul J, Saunders D, Bolle S, Cameron AL, Claude L, Gurtner K, van de Ven KP, van Grotel M, Harrabi S, Lassen-Ramshad Y, Lavan N, Magelssen H, Muracciole X, Boterberg T, Mandeville H, Godzinski J, Graf N, van den Heuvel-Eibrink MM, Rübe C
    • Issue date: 2020 Nov
    • Variability of clinical target volume delineation for rectal cancer patients planned for neoadjuvant radiotherapy with the aid of the platform Anatom-e.
    • Authors: Franco P, Arcadipane F, Trino E, Gallio E, Martini S, Iorio GC, Piva C, Moretto F, Ruo Redda MG, Verna R, Tseroni V, Bona C, Pozzi G, Fiandra C, Ragona R, Bertetto O, Ricardi U
    • Issue date: 2018 Jun
    • Quantitative assessment of inter-clinician variability of target volume delineation for medulloblastoma: quality assurance for the SIOP PNET 4 trial protocol.
    • Authors: Coles CE, Hoole AC, Harden SV, Burnet NG, Twyman N, Taylor RE, Kortmann RD, Williams MV
    • Issue date: 2003 Nov
    • Improving the accuracy and consistency of clinical target volume delineation for rectal cancer by an education program.
    • Authors: Zhang YZ, Zhu XG, Song MX, Yao KN, Li S, Geng JH, Wang HZ, Li YH, Cai Y, Wang WH
    • Issue date: 2022 May 15
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.