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dc.contributor.authorMosteo, L.
dc.contributor.authorStorer, J.
dc.contributor.authorBatta, K.
dc.contributor.authorSearle, Emma J
dc.contributor.authorDuarte, D.
dc.contributor.authorWiseman, Daniel H
dc.date.accessioned2021-04-20T08:08:22Z
dc.date.available2021-04-20T08:08:22Z
dc.date.issued2021en
dc.identifier.citationMosteo L, Storer J, Batta K, Searle EJ, Duarte D, Wiseman DH. The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy. Front Cell Dev Biol. 2021;9:635189.en
dc.identifier.pmid33777944en
dc.identifier.doi10.3389/fcell.2021.635189en
dc.identifier.urihttp://hdl.handle.net/10541/623943
dc.description.abstractHematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in "inflamm-aging" and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3389/fcell.2021.635189en
dc.titleThe dynamic interface between the bone marrow vascular niche and hematopoietic stem cells in myeloid malignancyen
dc.typeArticleen
dc.contributor.departmentInstituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugalen
dc.identifier.journalFrontiers in Cell and Developmental Biologyen
dc.description.noteen]
refterms.dateFOA2021-04-26T09:40:09Z


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