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    The dynamic interface between the bone marrow vascular niche and hematopoietic stem cells in myeloid malignancy

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    Authors
    Mosteo, L.
    Storer, J.
    Batta, K.
    Searle, Emma J
    Duarte, D.
    Wiseman, Daniel H
    Affiliation
    Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
    Issue Date
    2021
    
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    Abstract
    Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in "inflamm-aging" and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.
    Citation
    Mosteo L, Storer J, Batta K, Searle EJ, Duarte D, Wiseman DH. The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy. Front Cell Dev Biol. 2021;9:635189.
    Journal
    Frontiers in Cell and Developmental Biology
    URI
    http://hdl.handle.net/10541/623943
    DOI
    10.3389/fcell.2021.635189
    PubMed ID
    33777944
    Additional Links
    https://dx.doi.org/10.3389/fcell.2021.635189
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcell.2021.635189
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