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dc.contributor.authorDubec, Michael
dc.contributor.authorBrown, S
dc.contributor.authorChuter, Robert
dc.contributor.authorHales, Rosie
dc.contributor.authorWhiteside, Lee
dc.contributor.authorRodgers, John
dc.contributor.authorParker, Jacqui
dc.contributor.authorEccles, Cynthia L
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorFaivre-Finn, Corinne
dc.contributor.authorCobben, David
dc.date.accessioned2021-04-20T08:08:17Z
dc.date.available2021-04-20T08:08:17Z
dc.date.issued2021en
dc.identifier.citationDubec M, Brown S, Chuter R, Hales R, Whiteside L, Rodgers J, et al. MRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapy. Radiother Oncol. 2021;159:112-8.en
dc.identifier.pmid33775713en
dc.identifier.doi10.1016/j.radonc.2021.03.015en
dc.identifier.urihttp://hdl.handle.net/10541/623918
dc.description.abstractPurpose: This study compared MRI to CBCT for the identification and registration of lymph nodes (LN) in patients with locally advanced (LA)-NSCLC, to assess the suitability of targeting LNs in future MR-image guided radiotherapy (MRgRT) workflows. Method: Radiotherapy radiographers carried out Visual Grading Analysis (VGA) assessment of image quality, LN registration and graded their confidence in registration for each of the 24 LNs on CBCT and two MR sequences, MR1 (T2w Turbo Spin Echo) and MR2 (T1w DIXON water only image). Results: Pre-registration image quality assessment revealed MR1 and MR2 as significantly superior to CBCT in terms of image quality (p ≤ 0.01). No significant differences were noted in interobserver variability for LN registration between CBCT, MR1 and MR2. Observers were more confident in their MR registrations compared to their CBCT based LN registrations (p ≤ 0.02). Summary: Interobserver setup correction variability was not found to be significantly different between CBCT and MR. Image quality and registration confidence were found to be superior for MRI sequences. This is a promising step towards MR-guided radiotherapy for the treatment of LA-NSCLCen
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.radonc.2021.03.015en
dc.titleMRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapyen
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchesteren
dc.identifier.journalRadiotherapy and Oncologyen
dc.description.noteen]


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