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    Efficacy and safety results from CheckMate 140, a phase 2 study of nivolumab for relapsed/refractory follicular lymphoma

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    Authors
    Armand, P.
    Janssens, A.
    Gritti, G.
    Radford, John A
    Timmerman, J.
    Pinto, A.
    Vilchez, S. M.
    Johnson, P.
    Cunningham, D.
    Leonard, J. P.
    Rodig, S. J.
    Martin-Regueira, P.
    Sumbul, A.
    Samakoglu, S.
    Tang, H.
    Ansell, S. M.
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    Affiliation
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
    Issue Date
    2021
    
    Metadata
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    Abstract
    Nivolumab, an anti-programmed death-1 (PD-1) monoclonal antibody, showed promising activity in relapsed or refractory (R/R) follicular lymphoma (FL) in a phase 1 study. We conducted a phase 2 trial to further evaluate its efficacy and safety in patients with R/R FL and to explore biomarkers of response. Patients with R/R FL and at least 2 prior lines of therapy, each containing a CD20 antibody or an alkylating agent, were treated with nivolumab 3 mg/kg every 2 weeks. The primary end point was objective response rate (ORR) assessed by an independent radiologic review committee. Biomarker analyses included gene expression profiling and multiplex immunofluorescence studies of pretreatment tumor samples. A total of 92 patients were treated. After a minimum follow-up of 12 months, ORR was 4% (4 of 92 patients). Median progression-free survival (PFS) was 2.2 months (95% confidence interval [CI], 1.9-3.6 months). Median duration of response was 11 months (95% CI, 8-14 months). Exploratory analyses suggested that responders had significantly higher proportion of CD3+ T cells in the tumor microenvironment than nonresponders, but no significant differences in PD-1 or programmed death-ligand 1 expression were observed. High expression of a set of tumor-associated macrophage genes was associated with reduced PFS (hazard ratio, 3.28; 95% CI, 1.76-6.11; P = .001). The safety profile was consistent with previous reports of nivolumab. In conclusion, nivolumab monotherapy was associated with very limited activity in patients with R/R FL. Better understanding of the immune biology of this disease may facilitate the development of effective checkpoint-based strategies. This trial was registered at www.clinicaltrials.gov as #NCT02038946.
    Citation
    Armand P, Janssens A, Gritti G, Radford J, Timmerman J, Pinto A, et al. Efficacy and safety results from CheckMate 140, a phase 2 study of nivolumab for relapsed/refractory follicular lymphoma. Blood. 2021;137(5):637-45.
    Journal
    Blood
    URI
    http://hdl.handle.net/10541/623905
    DOI
    10.1182/blood.2019004753
    PubMed ID
    32870269
    Additional Links
    https://dx.doi.org/10.1182/blood.2019004753
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1182/blood.2019004753
    Scopus Count
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    All Christie Publications

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