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dc.contributor.authorNeo, W H
dc.contributor.authorLie-A-Ling, Michael
dc.contributor.authorFadlullah, Muhammad Z H
dc.contributor.authorLacaud, Georges
dc.date.accessioned2021-04-06T15:07:09Z
dc.date.available2021-04-06T15:07:09Z
dc.date.issued2021en
dc.identifier.citationNeo WH, Lie ALM, Fadlullah MZH, Lacaud G. Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System. Front Cell Dev Biol. 2021;9:631699.en
dc.identifier.pmid33681211en
dc.identifier.doi10.3389/fcell.2021.631699en
dc.identifier.urihttp://hdl.handle.net/10541/623888
dc.description.abstractDuring ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with the formation of hematopoietic stem cells (HSC). Initially, it was thought that HSC-independent hematopoietic YS cells were transient, and only required to bridge the gap to HSC activity. However, in recent years it has become clear that these cells also contribute to embryonic organogenesis, including the emergence of HSCs. Furthermore, some of these early HSC-independent YS cells persist into adulthood as distinct hematopoietic populations. These previously unrecognized abilities of embryonic HSC-independent hematopoietic cells constitute a new field of interest. Here, we aim to provide a succinct overview of the current knowledge regarding the contribution of YS-derived hematopoietic cells to the development of the embryo and the adult hematopoietic system.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3389/fcell.2021.631699en
dc.titleContributions of embryonic hsc-independent hematopoiesis to organogenesis and the adult hematopoietic systemen
dc.typeArticleen
dc.contributor.departmentStem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfielden
dc.identifier.journalFrontiers in cell and Development Biologyen
dc.description.noteen]
refterms.dateFOA2021-04-07T12:28:03Z


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