Contributions of embryonic hsc-independent hematopoiesis to organogenesis and the adult hematopoietic system
Affiliation
Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, MacclesfieldIssue Date
2021
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During ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with the formation of hematopoietic stem cells (HSC). Initially, it was thought that HSC-independent hematopoietic YS cells were transient, and only required to bridge the gap to HSC activity. However, in recent years it has become clear that these cells also contribute to embryonic organogenesis, including the emergence of HSCs. Furthermore, some of these early HSC-independent YS cells persist into adulthood as distinct hematopoietic populations. These previously unrecognized abilities of embryonic HSC-independent hematopoietic cells constitute a new field of interest. Here, we aim to provide a succinct overview of the current knowledge regarding the contribution of YS-derived hematopoietic cells to the development of the embryo and the adult hematopoietic system.Citation
Neo WH, Lie ALM, Fadlullah MZH, Lacaud G. Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System. Front Cell Dev Biol. 2021;9:631699.Journal
Frontiers in cell and Development BiologyDOI
10.3389/fcell.2021.631699PubMed ID
33681211Additional Links
https://dx.doi.org/10.3389/fcell.2021.631699Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3389/fcell.2021.631699
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