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    Contributions of embryonic hsc-independent hematopoiesis to organogenesis and the adult hematopoietic system

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    Authors
    Neo, W H
    Lie-A-Ling, Michael
    Fadlullah, Muhammad Z H
    Lacaud, Georges
    Affiliation
    Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfield
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    During ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with the formation of hematopoietic stem cells (HSC). Initially, it was thought that HSC-independent hematopoietic YS cells were transient, and only required to bridge the gap to HSC activity. However, in recent years it has become clear that these cells also contribute to embryonic organogenesis, including the emergence of HSCs. Furthermore, some of these early HSC-independent YS cells persist into adulthood as distinct hematopoietic populations. These previously unrecognized abilities of embryonic HSC-independent hematopoietic cells constitute a new field of interest. Here, we aim to provide a succinct overview of the current knowledge regarding the contribution of YS-derived hematopoietic cells to the development of the embryo and the adult hematopoietic system.
    Citation
    Neo WH, Lie ALM, Fadlullah MZH, Lacaud G. Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System. Front Cell Dev Biol. 2021;9:631699.
    Journal
    Frontiers in cell and Development Biology
    URI
    http://hdl.handle.net/10541/623888
    DOI
    10.3389/fcell.2021.631699
    PubMed ID
    33681211
    Additional Links
    https://dx.doi.org/10.3389/fcell.2021.631699
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcell.2021.631699
    Scopus Count
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    All Paterson Institute for Cancer Research

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