Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Authors
Huynh-Le, M. P.Fan, C. C.
Karunamuni, R.
Thompson, W. K.
Martinez, M. E.
Eeles, R. A.
Kote-Jarai, Z.
Muir, K.
Schleutker, J.
Pashayan, N.
Batra, J.
Grönberg, H.
Neal, D. E.
Donovan, J. L.
Hamdy, F. C.
Martin, R. M.
Nielsen, S. F.
Nordestgaard, B. G.
Wiklund, F.
Tangen, C. M.
Giles, G. G.
Wolk, A.
Albanes, D.
Travis, R. C.
Blot, W. J.
Zheng, W.
Sanderson, M.
Stanford, J. L.
Mucci, L. A.
West, Catharine M L
Kibel, A. S.
Cussenot, O.
Berndt, S. I.
Koutros, S.
Sørensen, K. D.
Cybulski, C.
Grindedal, E. M.
Menegaux, F.
Khaw, K. T.
Park, J. Y.
Ingles, S. A.
Maier, C.
Hamilton, R. J.
Thibodeau, S. N.
Rosenstein, B. S.
Lu, Y. J.
Watya, S.
Vega, A.
Kogevinas, M.
Penney, K. L.
Huff, C.
Teixeira, M. R.
Multigner, L.
Leach, R. J.
Cannon-Albright, L.
Brenner, H.
John, E. M.
Kaneva, R.
Logothetis, C. J.
Neuhausen, S. L.
De Ruyck, K.
Pandha, H.
Razack, A.
Newcomb, L. F.
Fowke, J. H.
Gamulin, M.
Usmani, N.
Claessens, F.
Gago-Dominguez, M.
Townsend, Paul A
Bush, W. S.
Roobol, M. J.
Parent, M.
Hu, J. J.
Mills, I. G.
Andreassen, O. A.
Dale, A. M.
Seibert, T. M.
Affiliation
Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA,Issue Date
2021
Metadata
Show full item recordAbstract
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.Citation
Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, et al. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nat Commun. 2021;12(1):1236.Journal
Nature CommunicationsDOI
10.1038/s41467-021-21287-0PubMed ID
33623038Additional Links
https://dx.doi.org/10.1038/s41467-021-21287-0Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41467-021-21287-0