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    Survival from breast cancer in women with a BRCA2 mutation by treatment

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    Authors
    Evans, D. G.
    Phillips, K. A.
    Milne, R. L.
    Fruscio, R.
    Cybulski, C.
    Gronwald, J.
    Lubinski, J.
    Huzarski, T.
    Hyder, Z.
    Forde, C.
    Metcalfe, K.
    Senter, L.
    Weitzel, J.
    Tung, N.
    Zakalik, D.
    Ekholm, Maria
    Sun, P.
    Narod, S. A.
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    Affiliation
    Genomic Medicine, Manchester Academic Health Science Centre, The University of Manchester, Manchester
    Issue Date
    2021
    
    Metadata
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    Abstract
    Background: The impact of various breast-cancer treatments on patients with a BRCA2 mutation has not been studied. We sought to estimate the impact of bilateral oophorectomy and other treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation. Methods: We identified 664 women with stage I-III breast cancer and a BRCA2 mutation by combining five different datasets (retrospective and prospective). Subjects were followed for 7.2 years from diagnosis to death from breast cancer. Tumour characteristics and cancer treatments were patient-reported and derived from medical records. Predictors of survival were determined using Cox proportional hazard models, adjusted for other treatments and for prognostic features. Results: The 10-year breast-cancer survival for ER-positive patients was 78.9% and for ER-negative patients was 82.3% (adjusted HR = 1.23 (95% CI, 0.62-2.45, p = 0.55)). The 10-year breast-cancer survival for women who had a bilateral oophorectomy was 89.1% and for women who did not have an oophorectomy was 59.0% (adjusted HR = 0.45; 95% CI, 0.28-0.72, p = 0.001). The adjusted hazard ratio for chemotherapy was 0.83 (95% CI, 0.65-1.53: p = 0.56). Conclusions: For women with breast cancer and a germline BRCA2 mutation, positive ER status does not predict superior survival. Oophorectomy is associated with a reduced risk of death from breast cancer and should be considered in the treatment plan.
    Citation
    Evans DG, Phillips KA, Milne RL, Fruscio R, Cybulski C, Gronwald J, et al. Survival from breast cancer in women with a BRCA2 mutation by treatment. Br J Cancer. 2021.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/623847
    DOI
    10.1038/s41416-020-01164-1
    PubMed ID
    33597716
    Additional Links
    https://dx.doi.org/10.1038/s41416-020-01164-1
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-020-01164-1
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