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    Cell of origin in biliary tract cancers and clinical implications

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    Authors
    Moeini, Agrin
    Haber, P. K.
    Sia, D.
    Affiliation
    Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Mancheste
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Biliary tract cancers (BTCs) are aggressive epithelial malignancies that can arise at any point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising steadily over the past 40 years, highlighting the need to improve current diagnostic and therapeutic strategies. BTCs show high inter- and intra-tumour heterogeneity both at the morphological and molecular level. Such complex heterogeneity poses a substantial obstacle to effective interventions. It is widely accepted that the observed heterogeneity may be the result of a complex interplay of different elements, including risk factors, distinct molecular alterations and multiple potential cells of origin. The use of genetic lineage tracing systems in experimental models has identified cholangiocytes, hepatocytes and/or progenitor-like cells as the cells of origin of BTCs. Genomic evidence in support of the distinct cell of origin hypotheses is growing. In this review, we focus on recent advances in the histopathological subtyping of BTCs, discuss current genomic evidence and outline lineage tracing studies that have contributed to the current knowledge surrounding the cell of origin of these tumours.
    Citation
    Moeini A, Haber PK, Sia D. Cell of origin in biliary tract cancers and clinical implications. JHEP Rep. 2021;3(2):100226.
    Journal
    JHEP Reports : innovations in hepatology
    URI
    http://hdl.handle.net/10541/623833
    DOI
    10.1016/j.jhepr.2021.100226
    PubMed ID
    33665585
    Additional Links
    https://dx.doi.org/10.1016/j.jhepr.2021.100226
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jhepr.2021.100226
    Scopus Count
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    All Paterson Institute for Cancer Research

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