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    Association of breast cancer irradiation with cardiac toxic effects: a narrative review

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    Authors
    Meattini, I.
    Poortmans, P. M.
    Aznar, Marianne Camille
    Becherini, C.
    Bonzano, E.
    Cardinale, D.
    Lenihan, D. J.
    Marrazzo, L.
    Curigliano, G.
    Livi, L.
    Affiliation
    Department of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, Florence, Italy.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Importance: To promptly recognize and manage cardiovascular (CV) risk factors before, during, and after cancer treatment, decreasing the risk of cancer therapy-related cardiac dysfunction is crucial. After recent advances in breast cancer treatment, mortality rates from cancer have decreased, and the prevalence of survivors with a potentially higher CV disease risk has increased. Cardiovascular risks might be associated with the multimodal approach, including systemic therapies and breast radiotherapy (RT). Observations: The heart disease risk seems to be higher in patients with tumors in the left breast, when other classic CV risk factors are present, and when adjunctive anthracycline-based chemotherapy is administered, suggesting a synergistic association. Respiratory control as well as modern RT techniques and their possible further refinement may decrease the prevalence and severity of radiation-induced heart disease. Several pharmacological cardioprevention strategies for decreasing cardiac toxic effects have been identified in several guidelines. However, further research is needed to ascertain the feasibility of these strategies in routine practice. Conclusions and relevance: This review found that evidence-based recommendations are lacking on the modalities for and intensity of heart disease screening, surveillance of patients after RT, and treatment of these patients. A multidisciplinary and multimodal approach is crucial to guide optimal management.
    Citation
    Meattini I, Poortmans PM, Aznar MC, Becherini C, Bonzano E, Cardinale D, et al. Association of Breast Cancer Irradiation With Cardiac Toxic Effects: A Narrative Review. JAMA Oncol. 2021.
    Journal
    JAMA Oncology
    URI
    http://hdl.handle.net/10541/623815
    DOI
    10.1001/jamaoncol.2020.7468
    PubMed ID
    33662107
    Additional Links
    https://dx.doi.org/10.1001/jamaoncol.2020.7468
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1001/jamaoncol.2020.7468
    Scopus Count
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    All Christie Publications

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