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dc.contributor.authorHynds, R. E.
dc.contributor.authorFrese, Kristopher K
dc.contributor.authorPearce, D. R.
dc.contributor.authorGrönroos, E.
dc.contributor.authorDive, Caroline
dc.contributor.authorSwanton, C.
dc.date.accessioned2021-03-08T06:18:51Z
dc.date.available2021-03-08T06:18:51Z
dc.date.issued2021en
dc.identifier.citationHynds RE, Frese KK, Pearce DR, Gronroos E, Dive C, Swanton C. Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories. Open Biol. 2021;11(1):200247.en
dc.identifier.pmid33435818en
dc.identifier.doi10.1098/rsob.200247en
dc.identifier.urihttp://hdl.handle.net/10541/623803
dc.description.abstractNon-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1098/rsob.200247en
dc.titleProgress towards non-small-cell lung cancer models that represent clinical evolutionary trajectoriesen
dc.typeArticleen
dc.contributor.departmentCancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.en
dc.identifier.journalOpen Biologyen
dc.description.noteen]
refterms.dateFOA2021-03-08T15:16:23Z


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