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dc.contributor.authorOrtega-Franco, Ana
dc.contributor.authorAckermann, C.
dc.contributor.authorPaz-Ares, L.
dc.contributor.authorCalifano, Raffaele
dc.date.accessioned2021-03-08T06:18:48Z
dc.date.available2021-03-08T06:18:48Z
dc.date.issued2021en
dc.identifier.citationOrtega-Franco A, Ackermann C, Paz-Ares L, Califano R. First-line immune checkpoint inhibitors for extensive stage small-cell lung cancer: clinical developments and future directions. ESMO Open. 2021;6(1):100003.en
dc.identifier.pmid33450659en
dc.identifier.doi10.1016/j.esmoop.2020.100003en
dc.identifier.urihttp://hdl.handle.net/10541/623788
dc.description.abstractSmall-cell lung cancer (SCLC) is an aggressive and rapidly growing disease with poor prognosis. Despite intense efforts to improve clinical outcomes, platinum/etoposide chemotherapy has remained the most effective regimen for first-line extensive disease SCLC for decades. The addition of immune checkpoint inhibitors, and specifically programmed death-ligand 1 inhibitors, to standard platinum/etoposide, significantly improves survival and represents a promising advance in this field. However, identification of a predictive biomarker to refine patient selection is an area of unmet need. Further understanding of tumour immunity and mechanism of resistance is required to design novel strategies that improve survival. In this review, we describe recent developments and future directions on first-line immune checkpoint blockade for extensive disease-SCLC.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.esmoop.2020.100003en
dc.titleFirst-line immune checkpoint inhibitors for extensive stage small-cell lung cancer: clinical developments and future directionsen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchesteren
dc.identifier.journalESMO Openen
dc.description.noteen]
refterms.dateFOA2021-03-08T13:49:20Z


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