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    First-line immune checkpoint inhibitors for extensive stage small-cell lung cancer: clinical developments and future directions

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    Authors
    Ortega-Franco, Ana
    Ackermann, C.
    Paz-Ares, L.
    Califano, Raffaele
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester
    Issue Date
    2021
    
    Metadata
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    Abstract
    Small-cell lung cancer (SCLC) is an aggressive and rapidly growing disease with poor prognosis. Despite intense efforts to improve clinical outcomes, platinum/etoposide chemotherapy has remained the most effective regimen for first-line extensive disease SCLC for decades. The addition of immune checkpoint inhibitors, and specifically programmed death-ligand 1 inhibitors, to standard platinum/etoposide, significantly improves survival and represents a promising advance in this field. However, identification of a predictive biomarker to refine patient selection is an area of unmet need. Further understanding of tumour immunity and mechanism of resistance is required to design novel strategies that improve survival. In this review, we describe recent developments and future directions on first-line immune checkpoint blockade for extensive disease-SCLC.
    Citation
    Ortega-Franco A, Ackermann C, Paz-Ares L, Califano R. First-line immune checkpoint inhibitors for extensive stage small-cell lung cancer: clinical developments and future directions. ESMO Open. 2021;6(1):100003.
    Journal
    ESMO Open
    URI
    http://hdl.handle.net/10541/623788
    DOI
    10.1016/j.esmoop.2020.100003
    PubMed ID
    33450659
    Additional Links
    https://dx.doi.org/10.1016/j.esmoop.2020.100003
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.esmoop.2020.100003
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