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dc.contributor.authorJohnson, N.
dc.contributor.authorMaguire, S.
dc.contributor.authorMorra, A.
dc.contributor.authorKapoor, P. M.
dc.contributor.authorTomczyk, K.
dc.contributor.authorJones, M. E.
dc.contributor.authorSchoemaker, M. J.
dc.contributor.authorGilham, C.
dc.contributor.authorBolla, M. K.
dc.contributor.authorWang, Q.
dc.contributor.authorDennis, J.
dc.contributor.authorAhearn, T. U.
dc.contributor.authorAndrulis, I. L.
dc.contributor.authorAnton-Culver, H.
dc.contributor.authorAntonenkova, N. N.
dc.contributor.authorArndt, V.
dc.contributor.authorAronson, K. J.
dc.contributor.authorAugustinsson, A.
dc.contributor.authorBaynes, C.
dc.contributor.authorFreeman, L. E. B.
dc.contributor.authorBeckmann, M. W.
dc.contributor.authorBenitez, J.
dc.contributor.authorBermisheva, M.
dc.contributor.authorBlomqvist, C.
dc.contributor.authorBoeckx, B.
dc.contributor.authorBogdanova, N. V.
dc.contributor.authorBojesen, S. E.
dc.contributor.authorBrauch, H.
dc.contributor.authorBrenner, H.
dc.contributor.authorBurwinkel, B.
dc.contributor.authorCampa, D.
dc.contributor.authorCanzian, F.
dc.contributor.authorCastelao, J. E.
dc.contributor.authorChanock, S. J.
dc.contributor.authorChenevix-Trench, G.
dc.contributor.authorClarke, C. L.
dc.contributor.authorConroy, D. M.
dc.contributor.authorCouch, F. J.
dc.contributor.authorCox, A.
dc.contributor.authorCross, S. S.
dc.contributor.authorCzene, K.
dc.contributor.authorDörk, T.
dc.contributor.authorEliassen, A. H.
dc.contributor.authorEngel, C.
dc.contributor.authorEvans, D. G.
dc.contributor.authorFasching, P. A.
dc.contributor.authorFigueroa, J.
dc.contributor.authorFloris, G.
dc.contributor.authorFlyger, H.
dc.contributor.authorGago-Dominguez, M.
dc.contributor.authorGapstur, S. M.
dc.contributor.authorGarcía-Closas, M.
dc.contributor.authorGaudet, M. M.
dc.contributor.authorGiles, G. G.
dc.contributor.authorGoldberg, M. S.
dc.contributor.authorGonzález-Neira, A.
dc.contributor.authorGuénel, P.
dc.contributor.authorHahnen, E.
dc.contributor.authorHaiman, C. A.
dc.contributor.authorHåkansson, N.
dc.contributor.authorHall, P.
dc.contributor.authorHamann, U.
dc.contributor.authorHarrington, P. A.
dc.contributor.authorHart, S. N.
dc.contributor.authorHooning, M. J.
dc.contributor.authorHopper, J. L.
dc.contributor.authorHowell, Anthony
dc.contributor.authorHunter, D. J.
dc.contributor.authorJager, A.
dc.contributor.authorJakubowska, A.
dc.contributor.authorJohn, E. M.
dc.contributor.authorKaaks, R.
dc.contributor.authorKeeman, R.
dc.contributor.authorKhusnutdinova, E.
dc.contributor.authorKitahara, C. M.
dc.contributor.authorKosma, V. M.
dc.contributor.authorKoutros, S.
dc.contributor.authorKraft, P.
dc.contributor.authorKristensen, V. N.
dc.contributor.authorKurian, A. W.
dc.contributor.authorLambrechts, D.
dc.contributor.authorLe Marchand, L.
dc.contributor.authorLinet, M.
dc.contributor.authorLubiński, J.
dc.contributor.authorMannermaa, A.
dc.contributor.authorManoukian, S.
dc.contributor.authorMargolin, S.
dc.contributor.authorMartens, J. W. M.
dc.contributor.authorMavroudis, D.
dc.contributor.authorMayes, R.
dc.contributor.authorMeindl, A.
dc.contributor.authorMilne, R. L.
dc.contributor.authorNeuhausen, S. L.
dc.contributor.authorNevanlinna, H.
dc.contributor.authorNewman, W. G.
dc.contributor.authorNielsen, S. F.
dc.contributor.authorNordestgaard, B. G.
dc.contributor.authorObi, N.
dc.contributor.authorOlshan, A. F.
dc.contributor.authorOlson, J. E.
dc.contributor.authorOlsson, H.
dc.contributor.authorOrban, E.
dc.contributor.authorPark-Simon, T. W.
dc.contributor.authorPeterlongo, P.
dc.contributor.authorPlaseska-Karanfilska, D.
dc.contributor.authorPylkäs, K.
dc.contributor.authorRennert, G.
dc.contributor.authorRennert, H. S.
dc.contributor.authorRuddy, K. J.
dc.contributor.authorSaloustros, E.
dc.contributor.authorSandler, D. P.
dc.contributor.authorSawyer, E. J.
dc.contributor.authorSchmutzler, R. K.
dc.contributor.authorScott, C.
dc.contributor.authorShu, X. O.
dc.contributor.authorSimard, J.
dc.contributor.authorSmichkoska, S.
dc.contributor.authorSohn, C.
dc.contributor.authorSouthey, M. C.
dc.contributor.authorSpinelli, J. J.
dc.contributor.authorStone, J.
dc.contributor.authorTamimi, R. M.
dc.contributor.authorTaylor, J. A.
dc.contributor.authorTollenaar, R.
dc.contributor.authorTomlinson, I.
dc.contributor.authorTroester, M. A.
dc.contributor.authorTruong, T.
dc.contributor.authorVachon, C. M.
dc.contributor.authorvan Veen, E. M.
dc.contributor.authorWang, S. S.
dc.contributor.authorWeinberg, C. R.
dc.contributor.authorWendt, C.
dc.contributor.authorWildiers, H.
dc.contributor.authorWinqvist, R.
dc.contributor.authorWolk, A.
dc.contributor.authorZheng, W.
dc.contributor.authorZiogas, A.
dc.contributor.authorDunning, A. M.
dc.contributor.authorPharoah, P. D. P.
dc.contributor.authorEaston, D. F.
dc.contributor.authorHowie, A. F.
dc.contributor.authorPeto, J.
dc.contributor.authorDos-Santos-Silva, I.
dc.contributor.authorSwerdlow, A. J.
dc.contributor.authorChang-Claude, J.
dc.contributor.authorSchmidt, M. K.
dc.contributor.authorOrr, N.
dc.contributor.authorFletcher, O.
dc.date.accessioned2021-03-08T06:18:47Z
dc.date.available2021-03-08T06:18:47Z
dc.date.issued2021en
dc.identifier.citationJohnson N, Maguire S, Morra A, Kapoor PM, Tomczyk K, Jones ME, et al. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. Br J Cancer. 2021;124(4):842-54.en
dc.identifier.pmid33495599en
dc.identifier.doi10.1038/s41416-020-01185-wen
dc.identifier.urihttp://hdl.handle.net/10541/623785
dc.description.abstractBackground: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10-8).en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41416-020-01185-wen
dc.titleCYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancersen
dc.typeArticleen
dc.contributor.departmentThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.en
dc.identifier.journalBritish Journal of Canceren
dc.description.noteen]
refterms.dateFOA2021-03-08T13:39:57Z


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