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    Haematological malignancy and nosocomial transmission are associated with an increased risk of death from COVID-19: results of a multi-center UK cohort

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    Authors
    Bhogal, T.
    Khan, U. T.
    Lee, Rebecca J
    Stockdale, A.
    Hesford, C.
    Potti-Dhananjaya, V.
    Jathanna, A.
    Rahman, S.
    Tivey, Ann
    Shotton, Rohan
    Sundar, R.
    Valerio, C.
    Norouzi, A.
    Walker, P.
    Suckling, R.
    Armstrong, Anne C
    Brearton, G.
    Pettitt, A.
    Kalakonda, N.
    Palmer, D. H.
    Jackson, R.
    Turtle, L.
    Palmieri, C.
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    Affiliation
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool,
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    The COVID-19 pandemic has been a disruptive event for cancer patients, especially those with haematological malignancies (HM). They may experience a more severe clinical course due to impaired immune responses. This multi-center retrospective UK audit identified cancer patients who had SARS-CoV-2 infection between 1 March and 10 June 2020 and collected data pertaining to cancer history, COVID-19 presentation and outcomes. In total, 179 patients were identified with a median age of 72 (IQR 61, 81) and follow-up of 44 days (IQR 42, 45). Forty-one percent were female and the overall mortality was 37%. Twenty-nine percent had HM and of these, those treated with chemotherapy in the preceding 28 days to COVID-19 diagnosis had worse outcome compared with solid malignancy (SM): 62% versus 19% died [HR 8.33 (95% CI, 2.56-25), p < 0.001]. Definite or probable nosocomial SARS-CoV-2 transmission accounted for 16% of cases and was associated with increased risk of death (HR 2.47, 95% CI 1.43-4.29, p = 0.001). Patients with haematological malignancies and those who acquire nosocomial transmission are at increased risk of death. Therefore, there is an urgent need to reassess shielding advice, reinforce stringent infection control, and ensure regular patient and staff testing to prevent nosocomial transmission.
    Citation
    Bhogal T, Khan UT, Lee R, Stockdale A, Hesford C, Potti-Dhananjaya V, et al. Haematological malignancy and nosocomial transmission are associated with an increased risk of death from COVID-19: results of a multi-center UK cohort. Leuk Lymphoma. 2021:1-16.
    Journal
    Leukemia and Lymphoma
    URI
    http://hdl.handle.net/10541/623775
    DOI
    10.1080/10428194.2021.1876865
    PubMed ID
    33508995
    Additional Links
    https://dx.doi.org/10.1080/10428194.2021.1876865
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1080/10428194.2021.1876865
    Scopus Count
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