• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Rothwell, Bethany C
    Kirkby, Norman
    Merchant, Michael J
    Chadwick, Amy
    Lowe, Matthew
    Mackay, Ranald I
    Hendry, Jolyon H
    Kirkby, Karen J
    Affiliation
    Division of Cancer Sciences, The University of Manchester Faculty of Biology Medicine and Health, Manchester
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxygen depletion paradigm of induced radioresistance. An example eight-dimensional parameter space demonstrates the conditions under which radiation may induce sufficient depletion of oxygen for a diffusion-limited hypoxic cellular response. Initial results support experimental evidence that FLASH sparing is only achieved for dose rates on the order of tens of Gy/s or higher, for a sufficiently high dose, and only for tissue that is slightly hypoxic at the time of radiation. We show that the FLASH effect is the result of a number of biological, radiochemical and delivery parameters. Also, the threshold dose for a FLASH effect occurring would be more prominent when the parameterisation was optimised to produce the maximum effect. The model provides a framework for further FLASH-related investigation and experimental design. An understanding of the mechanistic interactions producing an optimised FLASH effect is essential for its translation into clinical practice.
    Citation
    Rothwell BC, Kirkby NF, Merchant MJ, Chadwick AL, Lowe M, Mackay RI, et al. Determining the parameter space for effective oxygen depletion for FLASH radiation therapy. Phys Med Biol. 2021.
    Journal
    Physics in Medicine and Biology
    URI
    http://hdl.handle.net/10541/623762
    DOI
    10.1088/1361-6560/abe2ea
    PubMed ID
    33535191
    Additional Links
    https://dx.doi.org/10.1088/1361-6560/abe2ea
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1088/1361-6560/abe2ea
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • A microscopic oxygen transport model for ultra-high dose rate radiotherapy in vivo: The impact of physiological conditions on FLASH effect.
    • Authors: Guo L, Medin PM, Wang KK
    • Issue date: 2024 Nov
    • Two-dimensional oxygen-diffusion modelling for FLASH proton therapy with pencil beam scanning-Impact of diffusive tissue properties, dose, dose rate and scan patterns.
    • Authors: Diepeveen MH, Lathouwers D, José Santo R, Hoogeman MS, Habraken SJM
    • Issue date: 2024 Jul 24
    • Modeling the impact of spatial oxygen heterogeneity on radiolytic oxygen depletion during FLASH radiotherapy.
    • Authors: Taylor E, Hill RP, Létourneau D
    • Issue date: 2022 Jun 2
    • Modeling the impact of tissue oxygen profiles and oxygen depletion parameter uncertainties on biological response and therapeutic benefit of FLASH.
    • Authors: Zhu H, Schuemann J, Zhang Q, Gerweck LE
    • Issue date: 2024 Jan
    • Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at Conventional and FLASH Dose Rates.
    • Authors: Van Slyke AL, El Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim MM, Karagounis IV, Busch TM, Vinogradov SA, Koch CJ, Wiersma RD
    • Issue date: 2022 Aug 1
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.