• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Radiotherapy-immunotherapy combination: how will we bridge the gap between pre-clinical promise and effective clinical delivery?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    33530329.pdf
    Size:
    1.169Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Romano, Erminia
    Honeychurch, Jamie
    Illidge, Timothy M
    Affiliation
    Division of Cancer Sciences, Faculty of Biology, School of Medical Sciences, Medicine and Health, University of Manchester, Manchester M13 9P
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Radiotherapy (RT) is highly effective at directly killing tumor cells and plays an important part in cancer treatments being delivered to around 50% of all cancer patients. The additional immunomodulatory properties of RT have been investigated, and if exploited effectively, have the potential to further improve the efficacy of RT and cancer outcomes. The initial results of combining RT with immunomodulatory agents have generated promising data in pre-clinical studies, which has in turn led to a large number of RT and immunotherapy clinical trials. The overarching aim of these combinations is to enhance anti-tumor immune responses and improve responses rates and patient outcomes. In order to maximize this undoubted opportunity, there remain a number of important questions that need to be addressed, including: (i) the optimal RT dose and fractionation schedule; (ii) the optimal RT target volume; (iii) the optimal immuno-oncology (IO) agent(s) to partner with RT; (iv) the optimal site(s)/route(s) of administration of IO agents; and finally, the optimal RT schedule. In this review, we will summarize progress to date and identify current gaps in knowledge that need to be addressed in order to facilitate effective clinical translation of RT and IO agent combinations.
    Citation
    Romano E, Honeychurch J, Illidge TM. Radiotherapy-Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery? Cancers (Basel). 2021;13(3).
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/623761
    DOI
    10.3390/cancers13030457
    PubMed ID
    33530329
    Additional Links
    https://dx.doi.org/10.3390/cancers13030457
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13030457
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations.
    • Authors: Colton M, Cheadle EJ, Honeychurch J, Illidge TM
    • Issue date: 2020 Nov 4
    • Palliative extracranial radiotherapy in patients receiving immunotherapy for non-small cell lung cancer: a narrative review.
    • Authors: Kępka L
    • Issue date: 2023 Jan 30
    • Radiotherapy Dose in Patients Receiving Immunotherapy.
    • Authors: Fitzgerald KJ, Schoenfeld JD
    • Issue date: 2023 Jul
    • Treatment strategies and molecular mechanism of radiotherapy combined with immunotherapy in colorectal cancer.
    • Authors: Jin Y, Jiang J, Mao W, Bai M, Chen Q, Zhu J
    • Issue date: 2024 Jun 1
    • Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.
    • Authors: Ascierto PA, Agarwala S, Botti G, Cesano A, Ciliberto G, Davies MA, Demaria S, Dummer R, Eggermont AM, Ferrone S, Fu YX, Gajewski TF, Garbe C, Huber V, Khleif S, Krauthammer M, Lo RS, Masucci G, Palmieri G, Postow M, Puzanov I, Silk A, Spranger S, Stroncek DF, Tarhini A, Taube JM, Testori A, Wang E, Wargo JA, Yee C, Zarour H, Zitvogel L, Fox BA, Mozzillo N, Marincola FM, Thurin M
    • Issue date: 2016 Nov 15
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.