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dc.contributor.authorTarabichi, M.
dc.contributor.authorSalcedo, A.
dc.contributor.authorDeshwar, A. G.
dc.contributor.authorNi Leathlobhair, M.
dc.contributor.authorWintersinger, J.
dc.contributor.authorWedge, David C
dc.contributor.authorVan Loo, P.
dc.contributor.authorMorris, Q. D.
dc.contributor.authorBoutros, P. C.
dc.date.accessioned2021-01-25T01:13:53Z
dc.date.available2021-01-25T01:13:53Z
dc.date.issued2021en
dc.identifier.citationTarabichi M, Salcedo A, Deshwar AG, Ni Leathlobhair M, Wintersinger J, Wedge DC, et al. A practical guide to cancer subclonal reconstruction from DNA sequencing. Nat Methods. 2021.en
dc.identifier.pmid33398189en
dc.identifier.doi10.1038/s41592-020-01013-2en
dc.identifier.urihttp://hdl.handle.net/10541/623745
dc.description.abstractSubclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution studies, providing insight into the clonality and relative ordering of mutations and mutational processes. We provide an outline of the complex computational approaches used for subclonal reconstruction from single and multiple tumor samples. We identify the underlying assumptions and uncertainties in each step and suggest best practices for analysis and quality assessment. This guide provides a pragmatic resource for the growing user community of subclonal reconstruction methods.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41592-020-01013-2en
dc.titleA practical guide to cancer subclonal reconstruction from DNA sequencingen
dc.typeArticleen
dc.contributor.departmentThe Francis Crick Institute, London, UK.en
dc.identifier.journalNature Methodsen
dc.description.noteen]


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