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    A practical guide to cancer subclonal reconstruction from DNA sequencing

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    Authors
    Tarabichi, M.
    Salcedo, A.
    Deshwar, A. G.
    Ni Leathlobhair, M.
    Wintersinger, J.
    Wedge, David C
    Van Loo, P.
    Morris, Q. D.
    Boutros, P. C.
    Affiliation
    The Francis Crick Institute, London, UK.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution studies, providing insight into the clonality and relative ordering of mutations and mutational processes. We provide an outline of the complex computational approaches used for subclonal reconstruction from single and multiple tumor samples. We identify the underlying assumptions and uncertainties in each step and suggest best practices for analysis and quality assessment. This guide provides a pragmatic resource for the growing user community of subclonal reconstruction methods.
    Citation
    Tarabichi M, Salcedo A, Deshwar AG, Ni Leathlobhair M, Wintersinger J, Wedge DC, et al. A practical guide to cancer subclonal reconstruction from DNA sequencing. Nat Methods. 2021.
    Journal
    Nature Methods
    URI
    http://hdl.handle.net/10541/623745
    DOI
    10.1038/s41592-020-01013-2
    PubMed ID
    33398189
    Additional Links
    https://dx.doi.org/10.1038/s41592-020-01013-2
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41592-020-01013-2
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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