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    Nanomedicine: photo-activated nanostructured titanium dioxide, as a promising anticancer agent

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    Authors
    Lagopati, N.
    Evangelou, K.
    Falaras, P.
    Tsilibary, E. C.
    Vasileiou, P. V. S.
    Havaki, S.
    Angelopoulou, A.
    Pavlatou, E. A.
    Gorgoulis, Vassilis G
    Affiliation
    Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, 75, Mikras Asias Str., Goudi, GR 11527 Athens, Greece;
    Issue Date
    2020
    
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    Abstract
    The multivariate condition of cancer disease has been approached in various ways, by the scientific community. Recent studies focus on individualized treatments, minimizing the undesirable consequences of the conventional methods, but the development of an alternative effective therapeutic scheme remains to be held. Nanomedicine could provide a solution, filling this gap, exploiting the unique properties of innovative nanostructured materials. Nanostructured titanium dioxide (TiO2) has a variety of applications of daily routine and of advanced technology. Due to its biocompatibility, it has also a great number of biomedical applications. It is now clear that photo-excited TiO2 nanoparticles, induce generation of pairs of electrons and holes which react with water and oxygen to yield reactive oxygen species (ROS) that have been proven to damage cancer cells, triggering controlled cellular processes. The aim of this review is to provide insights into the field of nanomedicine and particularly into the wide context of TiO2-NP-mediated anticancer effect, shedding light on the achievements of nanotechnology and proposing this nanostructured material as a promising anticancer photosensitizer.
    Citation
    Lagopati N, Evangelou K, Falaras P, Tsilibary EC, Vasileiou PVS, Havaki S, et al. Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent. Pharmacol Ther. 2020;222:107795.
    Journal
    Pharmacology and Therapeutics
    URI
    http://hdl.handle.net/10541/623744
    DOI
    10.1016/j.pharmthera.2020.107795
    PubMed ID
    33358928
    Additional Links
    https://dx.doi.org/10.1016/j.pharmthera.2020.107795
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pharmthera.2020.107795
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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