• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Use of immunomodulating drugs and risk of cutaneous melanoma: a nationwide nested case-control study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    33376408.pdf
    Size:
    553.3Kb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Berge, L. A. M.
    Andreassen, B. K.
    Stenehjem, J. S.
    Heir, T.
    Karlstad, Ø.
    Juzeniene, A.
    Ghiasvand, R.
    Larsen, I. K.
    Green, Adèle C
    Veierød, M. B.
    Robsahm, T. E.
    Show allShow less
    Affiliation
    Department of Research, Cancer Registry of Norway, Oslo, Norway.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Purpose: Cutaneous melanoma is among the fastest growing malignancies in Norway and ultraviolet radiation (UVR) exposure is the primary environmental risk factor. Immunomodulating drugs can increase skin photosensitivity and suppress immune responses, and by such mechanisms influence melanoma risk. We, therefore, aimed to examine the associations between use of immunomodulating drugs and melanoma risk, at a nationwide population level. Patients and methods: In the Cancer Registry of Norway, we identified all cases aged 18-85 with a first primary cutaneous melanoma diagnosed in 2007-2015 (n=12,106). These were matched to population controls from the Norwegian National Registry 1:10 (n=118,564), on sex and year of birth using risk set sampling. Information on prescribed drugs (2004-2015) was obtained by linkage to the Norwegian Prescription Database (NorPD). Conditional logistic regression was used to estimate rate ratios (RRs) and 95% confidence intervals (CIs) for associations between use of immunomodulating drugs (immunosuppressants and corticosteroids) and melanoma risk, adjusted for ambient UVR and other drug use. Results: Compared with ≤1 prescription, use of ≥8 prescriptions of immunosuppressants was associated with increased risk of melanoma (RR 1.50, 95% CI 1.27, 1.77). Similar associations were found for subgroups of immunosuppressants: drugs typically prescribed to organ transplant recipients (OTRs) (RR 2.02, 95% CI 1.35, 3.03) and methotrexate (RR 1.27, 95% CI 1.04, 1.55). Similar results were found for high levels of cumulative doses and across all histological subtypes. Use of corticosteroids was not associated with melanoma risk. Conclusion: We found a positive association between use of immunosuppressants and melanoma risk, with the highest risk seen for drugs prescribed to OTRs. Knowledge about this risk increase is important for physicians and users of these drugs, for intensified surveillance, awareness and cautious sun exposure.
    Citation
    Berge LAM, Andreassen BK, Stenehjem JS, Heir T, Karlstad O, Juzeniene A, et al. Use of Immunomodulating Drugs and Risk of Cutaneous Melanoma: A Nationwide Nested Case-Control Study. Clin Epidemiol. 2020;12:1389-401.
    Journal
    Clinical Epidemiology
    URI
    http://hdl.handle.net/10541/623736
    DOI
    10.2147/clep.S269446
    PubMed ID
    33376408
    Additional Links
    https://dx.doi.org/10.2147/clep.S269446
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.2147/clep.S269446
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study.
    • Authors: Berge LAM, Andreassen BK, Stenehjem JS, Heir T, Furu K, Juzeniene A, Roscher I, Larsen IK, Green AC, Veierød MB, Robsahm TE
    • Issue date: 2020
    • Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study.
    • Authors: Berge LAM, Andreassen BK, Stenehjem JS, Larsen IK, Furu K, Juzeniene A, Roscher I, Heir T, Green A, Veierød MB, Robsahm TE
    • Issue date: 2019 Feb 20
    • Drugs with potential chemopreventive properties in relation to epithelial ovarian cancer--a nationwide case-control study.
    • Authors: Baandrup L
    • Issue date: 2015 Jul
    • Identification of potential carcinogenic and chemopreventive effects of prescription drugs: a protocol for a Norwegian registry-based study.
    • Authors: Andreassen BK, Støer NC, Martinsen JI, Ursin G, Weiderpass E, Thoresen GH, Debernard KB, Karlstad Ø, Pottegard A, Friis S
    • Issue date: 2019 Apr 8
    • Association of Phenotypic Characteristics and UV Radiation Exposure With Risk of Melanoma on Different Body Sites.
    • Authors: Ghiasvand R, Robsahm TE, Green AC, Rueegg CS, Weiderpass E, Lund E, Veierød MB
    • Issue date: 2019 Jan 1
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.