• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Prospects for personalised treatment of patients with radioiodine-avid locally recurrent or metastatic thyroid cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Beasley, M.
    Garcez, Kate
    Affiliation
    Bristol Cancer Institute, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol,
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Although most patients with metastatic or inoperable locally recurrent differentiated thyroid cancer have radioiodine-avid disease, the outcome for patients who do not achieve remission with radioiodine therapy is poor. Most centres use fixed empirical activities of radioiodine to treat these patients, which is in contrast to other areas of oncology, where there is a shift to more individualised treatment. The use of dosimetry techniques to calculate a more appropriate activity of radioiodine for each patient may increase the effectiveness of radioiodine therapy but is more complex, time-consuming and of unproven benefit. This review addresses some of the limitations of empirical radioiodine therapy, discusses existing dosimetry-based approaches to individualising therapy and proposes further work in this area. A prospective randomised controlled trial comparing empirical activities of radioiodine with activities guided by a combination of lesional dosimetry and maximum safe dose has not been carried out previously. Although considerable challenges in the design of such a study remain, a network of centres in the UK now has the potential to take this forward.
    Citation
    Beasley M, Garcez K. Prospects for Personalised Treatment of Patients with Radioiodine-avid Locally Recurrent or Metastatic Thyroid Cancer. Clin Oncol (R Coll Radiol). 2021;33(2):75-9.
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/623711
    DOI
    10.1016/j.clon.2020.11.010
    PubMed ID
    33339681
    Additional Links
    https://dx.doi.org/10.1016/j.clon.2020.11.010
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2020.11.010
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Indirect assessment of the maximum empirical activity (250 mCi) with respect to dosimetry concepts in radioiodine therapy of metastatic differentiated thyroid cancer.
    • Authors: Abuqbeitah M, Demir M, Kabasakal L, Çavdar İ, Uslu-Beşli L, Yeyin N, Razavikhosroshahi S, Sönmezoğlu K
    • Issue date: 2018 Nov
    • Juvenile differentiated thyroid carcinoma and the role of radioiodine in its treatment: a qualitative review.
    • Authors: Jarzab B, Handkiewicz-Junak D, Wloch J
    • Issue date: 2005 Dec
    • Peptide receptor radionuclide therapy for non-radioiodine-avid differentiated thyroid carcinoma.
    • Authors: Teunissen JJ, Kwekkeboom DJ, Kooij PP, Bakker WH, Krenning EP
    • Issue date: 2005 Jan
    • [Combined radioiodine (I131) treatment and radio-guided surgery for recurrent cervical well-differentiated thyroid cancer].
    • Authors: Schachter P, Shimonov M, Lorberboim M
    • Issue date: 2005 Mar
    • Radioiodine therapy for thyroid cancer in the era of risk stratification and alternative targeted therapies.
    • Authors: Pryma DA, Mandel SJ
    • Issue date: 2014 Sep
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.