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    Integrative p53, micro-RNA and cathepsin protease co-regulatory expression networks in cancer

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    Authors
    Soond, S. M.
    Kozhevnikova, M. V.
    Townsend, Paul A
    Zamyatnin, A. A., Jr.
    Affiliation
    Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya str. 8-2, 119991 Moscow, Russia.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    As the direct regulatory role of p53 and some of its isoform proteins are becoming established in modulating gene expression in cancer research, another aspect of this mode of gene regulation that has captured significant interest over the years is the mechanistic interplay between p53 and micro-RNA transcriptional regulation. The input of this into modulating gene expression for some of the cathepsin family members has been viewed as carrying noticeable importance based on their biological effects during normal cellular homeostasis and cancer progression. While this area is still in its infancy in relation to general cathepsin gene regulation, we review the current p53-regulated micro-RNAs that are generating significant interest through their regulation of cathepsin proteases, thereby strengthening the link between activated p53 forms and cathepsin gene regulation. Additionally, we extend our understanding of this developing relationship to how such micro-RNAs are being utilized as diagnostic or prognostic tools and highlight their future uses in conjunction with cathepsin gene expression as potential biomarkers within a clinical setting.
    Citation
    Soond SM, Kozhevnikova MV, Townsend PA, Zamyatnin AA, Jr. Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer. Cancers (Basel). 2020;12(11).
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/623676
    DOI
    10.3390/cancers12113454
    PubMed ID
    33233599
    Additional Links
    https://dx.doi.org/10.3390/cancers12113454
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers12113454
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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