Show simple item record

dc.contributor.authorPeek, G.
dc.contributor.authorOlsen, C. M.
dc.contributor.authorBaade, P.
dc.contributor.authorYoulden, D. R.
dc.contributor.authorAitken, J. F.
dc.contributor.authorGreen, Adèle C
dc.contributor.authorKhosrotehrani, K.
dc.date.accessioned2021-01-06T11:15:31Z
dc.date.available2021-01-06T11:15:31Z
dc.date.issued2020en
dc.identifier.citationPeek G, Olsen CM, Baade P, Youlden DR, Aitken JF, Green AC, et al. Survival in patients with multiple primary melanomas: Systematic review and meta-analysis. J Am Acad Dermatol. 2020;83(5):1406-14.en
dc.identifier.pmid32246965en
dc.identifier.doi10.1016/j.jaad.2020.03.076en
dc.identifier.urihttp://hdl.handle.net/10541/623672
dc.description.abstractBackground: The literature surrounding survival of patients with multiple primary melanomas (MPM) yields variable and opposing findings, constrained by statistical challenges. Objectives: To critically examine the available literature regarding survival of patients with MPM compared with a single primary melanoma and detail statistical methods used. Methods: Electronic searches were performed of PubMed, Embase, Web of Science, and Scopus, with cross-checking of references, for the period January 1956 to June 2019. Studies published in English examining survival in patients with multiple melanomas were included. Case studies and small case series were excluded. Results: There were 14 studies eligible for inclusion. Conclusions on survival varied markedly depending on the statistical method used. Four studies that accounted for survival bias by partitioning the survival time were included in the quantitative review, with 3 of these reporting a survival disadvantage for MPM, whereas the fourth showed no difference in survival. The pooled hazard ratio was 1.39 (95% confidence interval, 1.07-1.81) but with significant heterogeneity (I2 = 96.8%, Phet < .001). Limitations: Studies showed significant heterogeneity in methodology. Conclusion: When data were analyzed with robust statistical methods, patients with MPM had a survival disadvantage compared with patients with a single primary melanoma.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.jaad.2020.03.076en
dc.titleSurvival in patients with multiple primary melanomas: Systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentQueensland Skin and Cancer Foundation, Queensland Institute of Dermatology, South-Brisbane, Queensland, Australia.en
dc.identifier.journalJournal of the American Academy of Dermatologyen
dc.description.noteen]


Files in this item

This item appears in the following Collection(s)

Show simple item record