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    Survival in patients with multiple primary melanomas: Systematic review and meta-analysis

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    Authors
    Peek, G.
    Olsen, C. M.
    Baade, P.
    Youlden, D. R.
    Aitken, J. F.
    Green, Adèle C
    Khosrotehrani, K.
    Affiliation
    Queensland Skin and Cancer Foundation, Queensland Institute of Dermatology, South-Brisbane, Queensland, Australia.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Background: The literature surrounding survival of patients with multiple primary melanomas (MPM) yields variable and opposing findings, constrained by statistical challenges. Objectives: To critically examine the available literature regarding survival of patients with MPM compared with a single primary melanoma and detail statistical methods used. Methods: Electronic searches were performed of PubMed, Embase, Web of Science, and Scopus, with cross-checking of references, for the period January 1956 to June 2019. Studies published in English examining survival in patients with multiple melanomas were included. Case studies and small case series were excluded. Results: There were 14 studies eligible for inclusion. Conclusions on survival varied markedly depending on the statistical method used. Four studies that accounted for survival bias by partitioning the survival time were included in the quantitative review, with 3 of these reporting a survival disadvantage for MPM, whereas the fourth showed no difference in survival. The pooled hazard ratio was 1.39 (95% confidence interval, 1.07-1.81) but with significant heterogeneity (I2 = 96.8%, Phet < .001). Limitations: Studies showed significant heterogeneity in methodology. Conclusion: When data were analyzed with robust statistical methods, patients with MPM had a survival disadvantage compared with patients with a single primary melanoma.
    Citation
    Peek G, Olsen CM, Baade P, Youlden DR, Aitken JF, Green AC, et al. Survival in patients with multiple primary melanomas: Systematic review and meta-analysis. J Am Acad Dermatol. 2020;83(5):1406-14.
    Journal
    Journal of the American Academy of Dermatology
    URI
    http://hdl.handle.net/10541/623672
    DOI
    10.1016/j.jaad.2020.03.076
    PubMed ID
    32246965
    Additional Links
    https://dx.doi.org/10.1016/j.jaad.2020.03.076
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jaad.2020.03.076
    Scopus Count
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    All Paterson Institute for Cancer Research

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