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    Bladder preservation: translating discovery for clinical impact in urothelial cancer

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    Authors
    Miyamoto, D. T.
    Abbosh, P. H.
    West, Catharine M L
    Mouw, K. W.
    Affiliation
    Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Muscle-invasive bladder cancer can be treated with either radical cystectomy or bladder preservation approaches, and there is a need for reliable biomarkers to guide the optimal choice of therapy. The recent elucidation of the genomic landscape and biological drivers of bladder cancer has enabled the identification of tumor molecular features that may be helpful in driving clinical decision-making. Here, we summarize recent efforts to develop molecular biomarkers that could be leveraged to guide therapeutic decisions, post-treatment monitoring, and the optimal use of bladder preservation approaches for the effective treatment of muscle-invasive bladder cancer.
    Citation
    Miyamoto DT, Abbosh PH, West CML, Mouw KW. Bladder preservation: Translating discovery for clinical impact in urothelial cancer. Urol Oncol. 2020.
    Journal
    Urologic Oncology
    URI
    http://hdl.handle.net/10541/623669
    DOI
    10.1016/j.urolonc.2020.11.021
    PubMed ID
    33257220
    Additional Links
    https://dx.doi.org/10.1016/j.urolonc.2020.11.021
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.urolonc.2020.11.021
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