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    Circulating cell-free tumour DNA for early detection of pancreatic cancer

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    Authors
    Jaworski, J. J.
    Morgan, Robert David
    Sivakumar, S.
    Affiliation
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research for early detection is the use of circulating cell-free tumour DNA (ctDNA). The detection of ctDNA offers potential as a relatively non-invasive method of diagnosing pancreatic cancer by using genetic sequencing technology to detect tumour-specific mutational signatures in blood samples before symptoms manifest. These technologies are limited by a number of factors that lower sensitivity and specificity, including low levels of detectable ctDNA in early stage disease and contamination with non-cancer circulating cell-free DNA. However, genetic and epigenetic analysis of ctDNA in combination with other standard diagnostic tests may improve early detection rates. In this review, we evaluate the genetic and epigenetic methods under investigation in diagnosing pancreatic cancer and provide a perspective for future developments.
    Citation
    Jaworski JJ, Morgan RD, Sivakumar S. Circulating Cell-Free Tumour DNA for Early Detection of Pancreatic Cancer. Cancers (Basel). 2020;12(12).
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/623667
    DOI
    10.3390/cancers12123704
    PubMed ID
    33317202
    Additional Links
    https://dx.doi.org/10.3390/cancers12123704
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers12123704
    Scopus Count
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