• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Liquid biopsy in small cell lung cancer-a route to improved clinical care?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    33287165.pdf
    Size:
    1.716Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Church, Matt
    Carter, Louise
    Blackhall, Fiona H
    Affiliation
    Division of Cancer Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Small cell lung cancer (SCLC) has a particularly poor prognosis despite the high initial response to first-line systemic therapy, and there is a well-recognised lack of meaningful treatments beyond the second line. A number of reasons have been put forward to explain this, including a lack of common, easily-druggable genetic mutations in SCLC and rarity of high-quality tissue samples due to late presentation. Liquid biopsies, including circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) are increasingly used as surrogates for tumour tissue and have the advantage of being easily obtained serially to inform on the biology of disease progression and acquired chemoresistance, and may provide a pathway to improve care in this notoriously refractory disease. Here we discuss the current evidence behind these liquid biopsy methods in SCLC, and how they could be employed in future clinical care.
    Citation
    Church M, Carter L, Blackhall F. Liquid Biopsy in Small Cell Lung Cancer-A Route to Improved Clinical Care? Cells. 2020;9(12).
    Journal
    Cells
    URI
    http://hdl.handle.net/10541/623666
    DOI
    10.3390/cells9122586
    PubMed ID
    33287165
    Additional Links
    https://dx.doi.org/10.3390/cells9122586
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cells9122586
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • The predictive and prognostic significance of liquid biopsy in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: A prospective study.
    • Authors: Ding PN, Becker TM, Bray VJ, Chua W, Ma YF, Lynch D, Po J, Luk AWS, Caixeiro N, de Souza P, Roberts TL
    • Issue date: 2019 Aug
    • The clinical utility of circulating tumour cells in patients with small cell lung cancer.
    • Authors: Foy V, Fernandez-Gutierrez F, Faivre-Finn C, Dive C, Blackhall F
    • Issue date: 2017 Aug
    • [Liquid biopsy in colorectal cancer : An overview of ctDNA analysis in tumour diagnostics].
    • Authors: Haupts A, Roth W, Hartmann N
    • Issue date: 2019 Dec
    • Will liquid biopsies improve outcomes for patients with small-cell lung cancer?
    • Authors: Blackhall F, Frese KK, Simpson K, Kilgour E, Brady G, Dive C
    • Issue date: 2018 Sep
    • Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer.
    • Authors: Mondelo-Macía P, García-González J, León-Mateos L, Castillo-García A, López-López R, Muinelo-Romay L, Díaz-Peña R
    • Issue date: 2021 Jan 7
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.