Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: the AMEND-IT Trial
AuthorsEntwistle, T. R.
Keevil, B. G.
Green, Adèle C
Fildes, J. E.
AffiliationThe Ex-Vivo Lab, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
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AbstractCardiovascular disease (CVD) is common after cardiothoracic transplantation. In a pilot intervention we assessed feasibility and potential effectiveness of dietary interventions to reduce CVD risk. We recruited patients from a tertiary hospital and randomly allocated them to a Mediterranean or low-fat diet for twelve months. Feasibility was measured by patient participation, retention and adherence. Changes in weight, body mass index (BMI), heart rate, blood pressure, glucose markers and blood lipids were assessed using longitudinal Generalized Estimating Equation regression models with 95% confidence intervals. Of 56 heart and 60 lung transplant recipients, 52 (45%) consented, 41 were randomised and 39 (95%) completed the study with good adherence to randomized diets. After 12 months, changes in many risk factors were seen in the Mediterranean and low-fat diet groups respectively including mean BMI (-0.5 vs. 0.0kg/m2 ), systolic/diastolic blood pressure +0.5/+0.1 vs -4.4/-3.5 mmHg; fasting glucose -0.26 vs -0.27 mmol/L; total cholesterol -0.56 vs -0.40 mmol/L. Changes in BMI and systolic/diastolic blood pressure in 49 eligible patients who did not take part were +0.7 kg/m2 and +2.5/+1.8 mmHg. Thus such dietary interventions in cardiothoracic transplant patients are feasible, and potentially beneficial. A definitive nutritional intervention study in these high-risk patients is warranted.
CitationEntwistle TR, Miura K, Keevil BG, Morris J, Yonan N, Pohl M, et al. Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: The AMEND-IT Trial. Clin Transplant. 2020:e14186.
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- Issue date: 2018 Feb 14
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- Authors: Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E, Arós F, Conde M, Lahoz C, Lapetra J, Sáez G, Ros E, PREDIMED Study Investigators.
- Issue date: 2006 Jul 4
- Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials.
- Authors: Ge L, Sadeghirad B, Ball GDC, da Costa BR, Hitchcock CL, Svendrovski A, Kiflen R, Quadri K, Kwon HY, Karamouzian M, Adams-Webber T, Ahmed W, Damanhoury S, Zeraatkar D, Nikolakopoulou A, Tsuyuki RT, Tian J, Yang K, Guyatt GH, Johnston BC
- Issue date: 2020 Apr 1
- A very low-carbohydrate, low-saturated fat diet for type 2 diabetes management: a randomized trial.
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