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    Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: the AMEND-IT Trial

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    Authors
    Entwistle, T. R.
    Miura, K.
    Keevil, B. G.
    Morris, J.
    Yonan, N.
    Pohl, M.
    Green, Adèle C
    Fildes, J. E.
    Affiliation
    The Ex-Vivo Lab, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Cardiovascular disease (CVD) is common after cardiothoracic transplantation. In a pilot intervention we assessed feasibility and potential effectiveness of dietary interventions to reduce CVD risk. We recruited patients from a tertiary hospital and randomly allocated them to a Mediterranean or low-fat diet for twelve months. Feasibility was measured by patient participation, retention and adherence. Changes in weight, body mass index (BMI), heart rate, blood pressure, glucose markers and blood lipids were assessed using longitudinal Generalized Estimating Equation regression models with 95% confidence intervals. Of 56 heart and 60 lung transplant recipients, 52 (45%) consented, 41 were randomised and 39 (95%) completed the study with good adherence to randomized diets. After 12 months, changes in many risk factors were seen in the Mediterranean and low-fat diet groups respectively including mean BMI (-0.5 vs. 0.0kg/m2 ), systolic/diastolic blood pressure +0.5/+0.1 vs -4.4/-3.5 mmHg; fasting glucose -0.26 vs -0.27 mmol/L; total cholesterol -0.56 vs -0.40 mmol/L. Changes in BMI and systolic/diastolic blood pressure in 49 eligible patients who did not take part were +0.7 kg/m2 and +2.5/+1.8 mmHg. Thus such dietary interventions in cardiothoracic transplant patients are feasible, and potentially beneficial. A definitive nutritional intervention study in these high-risk patients is warranted.
    Citation
    Entwistle TR, Miura K, Keevil BG, Morris J, Yonan N, Pohl M, et al. Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: The AMEND-IT Trial. Clin Transplant. 2020:e14186.
    Journal
    Clinical Transplantation
    URI
    http://hdl.handle.net/10541/623655
    DOI
    10.1111/ctr.14186
    PubMed ID
    33314283
    Additional Links
    https://dx.doi.org/10.1111/ctr.14186
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/ctr.14186
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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