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    The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma

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    Authors
    Adderley, Helen
    Rack, S.
    Hapuarachi, B.
    Feeney, L.
    Morgan, D.
    Hussell, T.
    Wallace, A. J.
    Betts, G.
    Hodgson, C.
    Harrington, K.
    Metcalf, Robert
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    Affiliation
    The Christie NHS Foundation Trust, Manchester, United Kingdom.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Objectives: Despite wide excision and post-operative irradiation, loco-regional and/or metastatic recurrence is a significant clinical problem in salivary adenoid cystic carcinoma (SACC). Reliable biomarkers are required to tailor post-treatment surveillance to patients at highest risk of recurrence. We sought to determine the utility of TP53 and PIK3CA mutations as prognostic biomarkers in SACC. Materials and methods: DNA was extracted from archival tumour blocks of 145 SACC patients from 66 UK referral centres and sequenced for TP53 and PIK3CA mutations. Clinical, pathological and outcome data were analysed to determine the impact of the genomic alterations on disease recurrence and overall survival (OS). Results: TP53 and PIK3CA mutations were identified in 8% (10/121 successful analyses) and 2% (3/121) of cases, respectively. There were too few PIK3CA mutations in this cohort for informative further analysis. TP53-mutated SACC had significantly shorter median OS (5.3 vs. 16.3 years, p = 0.019) and lower 10-year survival (48% vs. 81%) compared with TP53 wild-type ACC. Solid-pattern histopathology was more frequent in TP53-mutated SACC (50% vs. 15%, p = 0.27). Conclusion: TP53-mutated recurrent and metastatic SACC was associated with shorter OS, which was significant when combined with published genomic data sets. Stratifying by TP53 status, in addition to established clinical, pathological and genomic biomarkers, may usefully inform follow-up strategy.
    Citation
    Adderley H, Rack S, Hapuarachi B, Feeney L, Morgan D, Hussell T, et al. The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma. Oral Oncol. 2020;113:105095.
    Journal
    Oral Oncology
    URI
    http://hdl.handle.net/10541/623623
    DOI
    10.1016/j.oraloncology.2020.105095
    PubMed ID
    33290961
    Additional Links
    https://dx.doi.org/10.1016/j.oraloncology.2020.105095
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.oraloncology.2020.105095
    Scopus Count
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    All Christie Publications

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