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dc.contributor.authorSekhar, Hema
dc.contributor.authorKochhar, Rohit
dc.contributor.authorCarrington, Bernadette M
dc.contributor.authorKaye, T.
dc.contributor.authorTolan, D.
dc.contributor.authorSaunders, Mark P
dc.contributor.authorSperrin, M.
dc.contributor.authorSebag-Montefiore, D.
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorRenehan, Andrew G
dc.date.accessioned2021-01-06T11:15:22Z
dc.date.available2021-01-06T11:15:22Z
dc.date.issued2020en
dc.identifier.citationSekhar H, Kochhar R, Carrington B, Kaye T, Tolan D, Saunders MP, et al. Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study. BMC Cancer. 2020;20(1):1165.en
dc.identifier.pmid33256671en
dc.identifier.doi10.1186/s12885-020-07613-7en
dc.identifier.urihttp://hdl.handle.net/10541/623621
dc.description.abstractBackground: The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure compared with standard maximal tumour diameter (1D) assessment in patients with squamous cell carcinoma of the anus undergoing chemoradiotherapy. Methods: We performed an early evaluation case-control study at two UK centres (2007-2014) in 39 patients with loco-regional failure (cases), and 41 patients disease-free at 3 years (controls). mrTV was determined using the summation of areas method (Volsum). Reproducibility was assessed using intraclass concordance correlation (ICC) and Bland-Altman limits of agreements. We derived receiver operating curves using logistic regression models and expressed accuracy as area under the curve (ROCAUC). Results: The median time per patient for Volsum quantification was 7.00 (inter-quartile range, IQR: 0.57-12.48) minutes. Intra and inter-observer reproducibilities were generally good (ICCs from 0.79 to 0.89) but with wide limits of agreement (intra-observer: - 28 to 31%; inter-observer: - 28 to 46%). Median mrTVs were greater for cases (32.6 IQR: 21.5-53.1 cm3) than controls (9.9 IQR: 5.7-18.1 cm3, p < 0.0001). The ROCAUC for mrT-size predicting loco-regional failure was 0.74 (95% CI: 0.63-0.85) improving to 0.82 (95% CI: 0.72-0.92) when replaced with mrTV (test for ROC differences, p = 0.024). Conclusion: Preliminary results suggest that the replacement of mrTV for mrT-size improves prediction of loco-regional failure after chemoradiotherapy for squamous cell carcinoma of the anus. However, mrTV calculation is time consuming and variation in its reproducibility are drawbacks with the current technology.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1186/s12885-020-07613-7en
dc.titleThree-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control studyen
dc.typeArticleen
dc.contributor.departmentDivision of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UKen
dc.identifier.journalBMC Canceren
dc.description.noteen]
refterms.dateFOA2021-01-06T12:51:23Z


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