• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    33256671.pdf
    Size:
    770Kb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Sekhar, Hema
    Kochhar, Rohit
    Carrington, Bernadette M
    Kaye, T.
    Tolan, D.
    Saunders, Mark P
    Sperrin, M.
    Sebag-Montefiore, D.
    van Herk, Marcel
    Renehan, Andrew G
    Affiliation
    Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Background: The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure compared with standard maximal tumour diameter (1D) assessment in patients with squamous cell carcinoma of the anus undergoing chemoradiotherapy. Methods: We performed an early evaluation case-control study at two UK centres (2007-2014) in 39 patients with loco-regional failure (cases), and 41 patients disease-free at 3 years (controls). mrTV was determined using the summation of areas method (Volsum). Reproducibility was assessed using intraclass concordance correlation (ICC) and Bland-Altman limits of agreements. We derived receiver operating curves using logistic regression models and expressed accuracy as area under the curve (ROCAUC). Results: The median time per patient for Volsum quantification was 7.00 (inter-quartile range, IQR: 0.57-12.48) minutes. Intra and inter-observer reproducibilities were generally good (ICCs from 0.79 to 0.89) but with wide limits of agreement (intra-observer: - 28 to 31%; inter-observer: - 28 to 46%). Median mrTVs were greater for cases (32.6 IQR: 21.5-53.1 cm3) than controls (9.9 IQR: 5.7-18.1 cm3, p < 0.0001). The ROCAUC for mrT-size predicting loco-regional failure was 0.74 (95% CI: 0.63-0.85) improving to 0.82 (95% CI: 0.72-0.92) when replaced with mrTV (test for ROC differences, p = 0.024). Conclusion: Preliminary results suggest that the replacement of mrTV for mrT-size improves prediction of loco-regional failure after chemoradiotherapy for squamous cell carcinoma of the anus. However, mrTV calculation is time consuming and variation in its reproducibility are drawbacks with the current technology.
    Citation
    Sekhar H, Kochhar R, Carrington B, Kaye T, Tolan D, Saunders MP, et al. Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study. BMC Cancer. 2020;20(1):1165.
    Journal
    BMC Cancer
    URI
    http://hdl.handle.net/10541/623621
    DOI
    10.1186/s12885-020-07613-7
    PubMed ID
    33256671
    Additional Links
    https://dx.doi.org/10.1186/s12885-020-07613-7
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12885-020-07613-7
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Pre-treatment magnetic resonance imaging in anal cancer: large-scale evaluation of mrT, mrN and novel staging parameters.
    • Authors: Sekhar H, Kochhar R, Carrington B, Kaye T, Tolan D, Malcomson L, Saunders MP, Sperrin M, Sebag-Montefiore D, van Herk M, Renehan AG
    • Issue date: 2024 Oct
    • Three-dimensional ultrasonography of the breast; An adequate replacement for MRI in neoadjuvant chemotherapy tumour response evaluation? - RESPONDER trial.
    • Authors: van Egdom LSE, Lagendijk M, Heijkoop EHM, Koning AHJ, van Deurzen CHM, Jager A, van Lankeren W, Koppert LB
    • Issue date: 2018 Jul
    • Pre-treatment magnetic resonance-based texture features as potential imaging biomarkers for predicting event free survival in anal cancer treated by chemoradiotherapy.
    • Authors: Hocquelet A, Auriac T, Perier C, Dromain C, Meyer M, Pinaquy JB, Denys A, Trillaud H, Denis De Senneville B, Vendrely V
    • Issue date: 2018 Jul
    • Definitive chemoradiotherapy for anal canal cancer: single-center experience.
    • Authors: Tachibana I, Nishimura Y, Inada M, Fukuda K, Ishikawa K, Nishikawa T, Yokokawa M, Nakamatsu K, Kanamori S, Hida JI
    • Issue date: 2018 Dec
    • Gross tumour volume delineation in anal cancer on T2-weighted and diffusion-weighted MRI - Reproducibility between radiologists and radiation oncologists and impact of reader experience level and DWI image quality.
    • Authors: Min LA, Vacher YJL, Dewit L, Donker M, Sofia C, van Triest B, Bos P, van Griethuysen JJW, Maas M, Beets-Tan RGH, Lambregts DMJ
    • Issue date: 2020 Sep
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.