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dc.contributor.authorPunjabi, A.
dc.contributor.authorBarrett, E.
dc.contributor.authorCheng, A.
dc.contributor.authorMulla, A.
dc.contributor.authorWalls, G.
dc.contributor.authorBurke, D.
dc.contributor.authorMcAleese, J.
dc.contributor.authorMoore, K.
dc.contributor.authorHicks, J.
dc.contributor.authorBlyth, K.
dc.contributor.authorDenholm, M.
dc.contributor.authorMagee, L.
dc.contributor.authorGilligan, D.
dc.contributor.authorSilverman, S.
dc.contributor.authorQureshi, M.
dc.contributor.authorHatton, M.
dc.contributor.authorClinch, H.
dc.contributor.authorPhilips, L.
dc.contributor.authorBrown, Sean
dc.contributor.authorMacdonald, F.
dc.contributor.authorFaivre-Finn, Corinne
dc.contributor.authorHiley, C.
dc.contributor.authorEvison, M.
dc.date.accessioned2021-01-06T11:15:18Z
dc.date.available2021-01-06T11:15:18Z
dc.date.issued2020en
dc.identifier.citationPunjabi A, Barrett E, Cheng A, Mulla A, Walls G, Burke D, et al. Neutrophil lymphocyte ratio as a prognostic marker in patients treated with curative intent radiotherapy for non-small cell lung cancer. Lung Cancer. 2020;139:S41-S2en
dc.identifier.urihttp://hdl.handle.net/10541/623598
dc.description.abstractIntroduction: Neutrophil lymphocyte ratio (NLR), a marker of systemic inflammation, has been found to have prognostic significance in patients with non-small cell lung cancer (NSCLC) in various studies. In this retrospective study we look at the impact of NLR and the change in NLR in patients treated with different modalities of curative intent radiotherapy (RT) for NSCLC. Methods: We retrospectively analysed data from consecutive patients who underwent curative intent RT for NSCLC across 9 sites in UK from 01/10/2014 to 01/10/2016.Outcomes recorded included disease recurrence and death (cancer vs non-cancer related).425 patients had their pre ( within 6 weeks) and post treatment values (up to 4 weeks) recorded who were included in the final analysis. Potential prognostic factors such as age, performance status and disease stage were analysed. The survival rates were estimated with Kaplan-Meier analysis. Univariate and multivariate analysis using the Cox proportional hazards model were performed. Results: 425 patients were followed up for 2 years. Recurrence and death during the follow up were seen in 52% and 61% respectively. Higher NLR pre and post were both associated with poorer overall survival (OS; p<0.05). Receiver operator curve analysis found pre NLR >2.18 (OR 1.9, CI 1.21–3.03; p<0.001) and post NLR >5.26 (OR 2.65, CI 1.75–4.06; p<0.001) and difference in NLR( pre and post treatment ) >6.2 (OR 1.97, CI 1.43–2.7; p<0.001) optimally predicted poor overall survival on both univariate and multivariate analysis. Pre and post NLR were not significantly associated with recurrence outcomes. However, difference in NLR >–4.5 (OR 0.24, CI 0.12–0.48; p=0001) predicted lower risk of recurrence. Conclusion: This study shows that NLR, a surrogate marker for systemic inflammation, has prognostic value in NSCLC patients treated with curative intent radiotherapy. Further studies are needed to evaluate its utility in predictive models for response to radiotherapy to correlate with potential influencing factors such as irradiated volume parameters and choice of systemic therapy.en
dc.language.isoenen
dc.titleNeutrophil lymphocyte ratio as a prognostic marker in patients treated with curative intent radiotherapy for non-small cell lung canceren
dc.typeMeetings and Proceedingsen
dc.contributor.departmentWythenshawe Hospital, Manchesteren
dc.identifier.journalLung Canceren
dc.description.noteen]


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