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    Spontaneous aortic haematoma in a patient receiving adjuvant folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin chemotherapy following resection of a pancreatic adenocarcinoma

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    Authors
    Dacie, Ruth
    Woodhouse, Laura
    Mullan, Damian
    Lamarca, Angela
    Affiliation
    Medical Oncology, The Christie NHS Foundation Trust, Manchester, GBR.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    This case report describes the finding of a spontaneous aortic haematoma in a patient receiving adjuvant folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) chemotherapy following resection of a pancreatic adenocarcinoma. The haematoma was thought to have arisen secondary to a chemotherapy-induced vasculitis affecting the aorta, as the patient had no other risk factors for de novo aortitis or aortic haematoma. There have been several previously documented cases of associations between chemotherapy agents (in particular platinum-based agents) and vasculitis. This report includes computed tomography (CT) images and a discussion of the literature of related cases. This case is a good example of rare vascular toxicities arising from chemotherapy, the impact such rare complications have upon further chemotherapy options, and how these should be discussed when consenting patients for chemotherapy due to the potentially life-threatening complications.
    Citation
    Dacie R, Woodhouse L, Mullan D, Lamarca A. Spontaneous Aortic Haematoma in a Patient Receiving Adjuvant Folinic Acid, 5-Fluorouracil, Irinotecan, and Oxaliplatin Chemotherapy Following Resection of a Pancreatic Adenocarcinoma. Cureus. 2020;12(10):e10908.
    Journal
    Cureus
    URI
    http://hdl.handle.net/10541/623570
    DOI
    10.7759/cureus.10908
    PubMed ID
    33194475
    Additional Links
    https://dx.doi.org/10.7759/cureus.10908
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.7759/cureus.10908
    Scopus Count
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