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dc.contributor.authorMaltas, Joe
dc.contributor.authorReed, Hannah
dc.contributor.authorPorter, Andrew P
dc.contributor.authorMalliri, Angeliki
dc.date.accessioned2020-12-08T05:36:44Z
dc.date.available2020-12-08T05:36:44Z
dc.date.issued2020en
dc.identifier.citationMaltas J, Reed H, Porter A, Malliri A. Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease. Biochem Soc Trans. 2020.en
dc.identifier.pmid33200195en
dc.identifier.doi10.1042/bst20200481en
dc.identifier.urihttp://hdl.handle.net/10541/623568
dc.description.abstractThe Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1042/bst20200481en
dc.titleMechanisms and consequences of dysregulation of the Tiam family of Rac activators in diseaseen
dc.typeArticleen
dc.contributor.departmentCell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.en
dc.identifier.journalBiochemical Society Transactionsen
dc.description.noteen]


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