Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease
Affiliation
Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.Issue Date
2020
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The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease.Citation
Maltas J, Reed H, Porter A, Malliri A. Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease. Biochem Soc Trans. 2020.Journal
Biochemical Society TransactionsDOI
10.1042/bst20200481PubMed ID
33200195Additional Links
https://dx.doi.org/10.1042/bst20200481Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1042/bst20200481
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