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    Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease

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    Authors
    Maltas, Joe
    Reed, Hannah
    Porter, Andrew P
    Malliri, Angeliki
    Affiliation
    Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease.
    Citation
    Maltas J, Reed H, Porter A, Malliri A. Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease. Biochem Soc Trans. 2020.
    Journal
    Biochemical Society Transactions
    URI
    http://hdl.handle.net/10541/623568
    DOI
    10.1042/bst20200481
    PubMed ID
    33200195
    Additional Links
    https://dx.doi.org/10.1042/bst20200481
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1042/bst20200481
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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