Therapeutic strategies for the management of hormone receptor-positive, human epidermal growth factor receptor 2-positive (HR+/HER2+) breast cancer: a review of the current literature
Authors
Thanopoulou, E.Khader, L.
Caira, M.
Wardley, Andrew M
Ettl, J.
Miglietta, F.
Neven, P.
Guarneri, V.
Affiliation
Eli Lilly and Company Limited, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.Issue Date
2020
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Show full item recordAbstract
Enormous advances have been made in the understanding and treatment of human epidermal growth factor receptor 2-positive breast cancer (HER2+ BC) in the last 30 years that have resulted in survival gains for affected patients. A growing body of evidence suggests that hormone receptor-positive (HR+)/HER2+ BC and HR-negative (HR-)/HER2+ BC are biologically different, with complex molecular bidirectional crosstalk between the estrogen receptor and HER2 pathway potentially affecting sensitivity to both HER2-targeted and endocrine therapy in patients with HR+/HER2+ BC. Subgroup analyses from trials enrolling patients with HER2+ BC and the results of clinical trials specifically designed to evaluate therapy in patients with HR+/HER2+ BC are helping to guide treatment decisions. In this context, encouraging results with strategies aimed at delaying or reversing drug resistance, including extended adjuvant therapy and the addition of drugs targeting alternative pathways, such as cyclin-dependent kinase (CDK) 4 and 6 inhibitors, have recently emerged. We have reached the point where tailoring the treatment according to risk and biology has become the paradigm in early BC. However, further clinical trials are needed that integrate translational research principles and identify and consider specific patient subgroups and biomarkers.Citation
Thanopoulou E, Khader L, Caira M, Wardley A, Ettl J, Miglietta F, et al. Therapeutic Strategies for the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Positive (HR+/HER2+) Breast Cancer: A Review of the Current Literature. Cancers (Basel). 2020;12(11).Journal
CancersDOI
10.3390/cancers12113317PubMed ID
33182657Additional Links
https://dx.doi.org/10.3390/cancers12113317Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/cancers12113317
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