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CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

dc.contributor.authorWalls, G. M.
dc.contributor.authorOughton, J. B.
dc.contributor.authorChalmers, A. J.
dc.contributor.authorBrown, S.
dc.contributor.authorCollinson, F.
dc.contributor.authorForster, M. D.
dc.contributor.authorFranks, K. N.
dc.contributor.authorGilbert, A.
dc.contributor.authorHanna, G. G.
dc.contributor.authorHannaway, N.
dc.contributor.authorHarrow, S.
dc.contributor.authorHaswell, T.
dc.contributor.authorHiley, C. T.
dc.contributor.authorHinsley, S.
dc.contributor.authorKrebs, Matthew G
dc.contributor.authorMurden, G.
dc.contributor.authorPhillip, R.
dc.contributor.authorRyan, A. J.
dc.contributor.authorSalem, Ahmed
dc.contributor.authorSebag-Montefoire, D.
dc.contributor.authorShaw, P.
dc.contributor.authorTwelves, C. J.
dc.contributor.authorWalker, K.
dc.contributor.authorYoung, R. J.
dc.contributor.authorFaivre-Finn, C.
dc.contributor.authorGreystoke, A.
dc.date.accessioned2020-11-16T07:49:18Z
dc.date.available2020-11-16T07:49:18Z
dc.date.issued2020en
dc.identifier.citationWalls GM, Oughton JB, Chalmers AJ, Brown S, Collinson F, Forster MD, et al. CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer. Clin Transl Radiat Oncol. 2020;25:61-6.en
dc.identifier.pmid33072895en
dc.identifier.doi10.1016/j.ctro.2020.09.006en
dc.identifier.urihttp://hdl.handle.net/10541/623448
dc.description.abstractLung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for 'gold standard' treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.ctro.2020.09.006en
dc.titleCONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung canceren
dc.typeArticleen
dc.contributor.departmentPatrick G Johnston Centre for Cancer Research, Queen's University Belfast, Northern Ireland, UK.en
dc.identifier.journalClinical and Translational Radiation Oncologyen
dc.description.noteen]
refterms.dateFOA2020-11-17T09:20:10Z


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