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    CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

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    Authors
    Walls, G. M.
    Oughton, J. B.
    Chalmers, A. J.
    Brown, S.
    Collinson, F.
    Forster, M. D.
    Franks, K. N.
    Gilbert, A.
    Hanna, G. G.
    Hannaway, N.
    Harrow, S.
    Haswell, T.
    Hiley, C. T.
    Hinsley, S.
    Krebs, Matthew G
    Murden, G.
    Phillip, R.
    Ryan, A. J.
    Salem, Ahmed
    Sebag-Montefoire, D.
    Shaw, P.
    Twelves, C. J.
    Walker, K.
    Young, R. J.
    Faivre-Finn, C.
    Greystoke, A.
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    Affiliation
    Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Northern Ireland, UK.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for 'gold standard' treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding.
    Citation
    Walls GM, Oughton JB, Chalmers AJ, Brown S, Collinson F, Forster MD, et al. CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer. Clin Transl Radiat Oncol. 2020;25:61-6.
    Journal
    Clinical and Translational Radiation Oncology
    URI
    http://hdl.handle.net/10541/623448
    DOI
    10.1016/j.ctro.2020.09.006
    PubMed ID
    33072895
    Additional Links
    https://dx.doi.org/10.1016/j.ctro.2020.09.006
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctro.2020.09.006
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